HL-A Antigens on Leukaemic Cells
| Autor: | Valerie L. Middleton, I. C. Balfour, Carol A. Evans, G. D. Pegrum |
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| Rok vydání: | 1970 |
| Předmět: |
Isoantigens
Population Antigen Leukocytes medicine Genetic predisposition Humans education Kidney transplantation Kidney education.field_of_study Leukemia business.industry Lymphoma Non-Hodgkin Hematology medicine.disease Kidney Transplantation Tissue Donors Leukemia Lymphoid Transplantation Leukemia Myeloid Acute medicine.anatomical_structure Acute Disease Chronic Disease Immunology business |
| Zdroj: | British Journal of Haematology. 19:493-498 |
| ISSN: | 1365-2141 0007-1048 |
| DOI: | 10.1111/j.1365-2141.1970.tb06977.x |
| Popis: | Summary. The peripheral blood leucocytes from 26 leukaemic patients have been typed using alloantisera which recognize 13 HL-A specificities. The results show a marked increase in the incidence of HL-A 3, some increase in certain other HL-A antigens, and a slighty reduced frequency of HL-A 2, as compared with a population of healthy volunteers, kidney donors and patients awaiting renal transplantation. These findings suggest that leukaemic cells either react differently to the alloantisera or that additional tumour-specific antigens are present on the cells. Another possibility is that persons with these antigenic configurations have a genetic predisposition to develop leukaemia. Further studies on leucocytes from patients with various types of leukaemia and from different population groups will be needed to confirm these findings. |
| Databáze: | OpenAIRE |
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