Downregulation of toll-like receptor-mediated signalling pathways in oral lichen planus
| Autor: | Fiona A Firth, Trudy J. Milne, Suraya Hani Mohd. Sinon, Alison M. Rich, V. P. B. Parachuru, Gregory J. Seymour |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
0301 basic medicine TIRAP Cancer Research medicine.medical_specialty MAPK8 Down-Regulation Biology Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine stomatognathic system Downregulation and upregulation Internal medicine medicine Humans HSP70 Heat-Shock Proteins HMGB1 Protein Receptor Membrane Glycoproteins Toll-Like Receptors Mouth Mucosa Receptors Interleukin-1 Middle Aged medicine.disease Immunohistochemistry Up-Regulation stomatognathic diseases TLR2 030104 developmental biology Endocrinology Otorhinolaryngology 030220 oncology & carcinogenesis Myeloid Differentiation Factor 88 Immunology TLR4 Periodontics Female Oral lichen planus Oral Surgery Lichen Planus Oral Signal Transduction |
| Zdroj: | Journal of Oral Pathology & Medicine. 45:28-34 |
| ISSN: | 0904-2512 |
| DOI: | 10.1111/jop.12319 |
| Popis: | Objective The objective of this study was to investigate the expression of Toll-like receptors (TLR) and TLR-associated signalling pathway genes in oral lichen planus (OLP). Methods Initially, immunohistochemistry was used to determine TLR expression in 12 formalin-fixed archival OLP tissues with 12 non-specifically inflamed oral tissues as controls. RNA was isolated from further fresh samples of OLP and non-specifically inflamed oral tissue controls (n = 6 for both groups) and used in qRT2-PCR focused arrays to determine the expression of TLRs and associated signalling pathway genes. Genes with a statistical significance of ±two-fold regulation (FR) and a P-value |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text