Comparative effects of the crude methanol/methylene chloride extract and fractions of Senecio biafrae (Oliv. & Hiern) J. Moore on some fertility parameters in immature female Wistar rats
| Autor: | Balé Bayala, Landry Lienou Lienou, Bruno Phelix Telefo, Charlotte Nangue, Richard Simo Tagne, Ana Paula Ribeiro Rodrigues, Gildas Tetaping Mbemya, Stephanie Chekem Goka, Nathalie Jiatsa Donfack, Didiane Mefokou Yemele |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Microbiology (medical)
lcsh:Arctic medicine. Tropical medicine lcsh:RC955-962 Ethyl acetate Uterus lcsh:Medicine Ovary Biology Crude extract Chloride Andrology Toxicology chemistry.chemical_compound Senecio biafrae medicine Fractions Cholesterol lcsh:R Blood proteins Infectious Diseases medicine.anatomical_structure Fertility chemistry Luteinizing hormone medicine.drug Hormone |
| Zdroj: | Asian Pacific Journal of Tropical Disease, Vol 5, Iss 5, Pp 404-411 (2015) |
| ISSN: | 2222-1808 |
| Popis: | Objective: To assay the comparative effect of Senecio biafrae leaves and stems methanol/ methylene chloride extract as well as its hexane, n-butanol and ethyl acetate fractions on reproductive function of immature female rat. Methods: Various doses of the methanol/methylene chloride extract and fractions were orally administered for 20 consecutive days to immature female rats. The parameters of the rats such as body, ovarian and uterus weight, uterine, ovarian and serum proteins, ovarian cholesterol as well as follicle-stimulating hormone, luteinizing hormone, estradiol and progesterone levels were recorded. Results: Levels of ovarian cholesterol and protein as well as uterine protein were doubled principally in animals treated with the ethyl acetate fraction not matter what dose was administered. The animals treated with crude extract presented a significant increase (P < 0.05) of 108%, 79% and 135% in serum estradiol level at the dose of 8 mg/kg, 32 mg/kg and 64 mg/ kg respectively. Conclusions: Results of the present study provide evidence on the inducing effect of the methanol/methylene chloride extract of S. biafrae and its fractions on immature female rat’s fertility parameters in serum, ovary and uterus. |
| Databáze: | OpenAIRE |
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