Exercise Capacity and Mortality in Older Men
| Autor: | Michael Greenberg, Jonathan Myers, Demosthenes B. Panagiotakos, John Peter Kokkinos, Michael Doumas, Vasilios Papademetriou, Charles Faselis, Pamela Karasik, Athanasios J. Manolis, Andreas Pittaras, Ross D. Fletcher, Peter Kokkinos |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Gerontology Aging medicine.medical_specialty Physical exercise Metabolic equivalent Cohort Studies Physiology (medical) Epidemiology medicine Humans Mortality Exercise Veterans Affairs Aged Proportional Hazards Models Aged 80 and over business.industry Hazard ratio Follow up studies Exercise capacity Confidence interval Physical Fitness Cardiology and Cardiovascular Medicine business Follow-Up Studies Demography |
| Zdroj: | Circulation. 122:790-797 |
| ISSN: | 1524-4539 0009-7322 |
| DOI: | 10.1161/circulationaha.110.938852 |
| Popis: | Background— Epidemiological findings, based largely on middle-aged populations, support an inverse and independent association between exercise capacity and mortality risk. The information available in older individuals is limited. Methods and Results— Between 1986 and 2008, we assessed the association between exercise capacity and all-cause mortality in 5314 male veterans aged 65 to 92 years (mean±SD, 71.4±5.0 years) who completed an exercise test at the Veterans Affairs Medical Centers in Washington, DC, and Palo Alto, Calif. We established fitness categories based on peak metabolic equivalents (METs) achieved. During a median 8.1 years of follow-up (range, 0.1 to 25.3), there were 2137 deaths. Baseline exercise capacity was 6.3±2.4 METs among survivors and 5.3±2.0 METs in those who died ( P 9 METs, regardless of age. Unfit individuals who improved their fitness status with serial testing had a 35% lower mortality risk (hazard ratio=0.65; confidence interval, 0.46 to 0.93) compared with those who remained unfit. Conclusions— Exercise capacity is an independent predictor of all-cause mortality in older men. The relationship is inverse and graded, with most survival benefits achieved in those with an exercise capacity >5 METs. Survival improved significantly when unfit individuals became fit. |
| Databáze: | OpenAIRE |
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