Antifungal activity of magnolol and honokiol
| Autor: | MinKyun Na, Kyu Ho Bang, KiHwan Bae, Byung Sun Min, Yoon Kwan Kim, Young Ha Rhee, Jong Pill Lee |
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| Rok vydání: | 2000 |
| Předmět: |
Cryptococcus neoformans
Honokiol Antifungal Agents biology Traditional medicine Epidermophyton floccosum Biphenyl Compounds Organic Chemistry Aspergillus niger Microbial Sensitivity Tests biology.organism_classification Lignans Corpus albicans Magnolol Microbiology chemistry.chemical_compound chemistry visual_art Drug Discovery visual_art.visual_art_medium Humans Molecular Medicine Bark Magnolia obovata |
| Zdroj: | Archives of Pharmacal Research. 23:46-49 |
| ISSN: | 1976-3786 0253-6269 |
| DOI: | 10.1007/bf02976465 |
| Popis: | Two neolignan compounds, magnolol (5,5'-diallyl-2,2'-dihydroxybiphenyl, 1) and honokiol (5,5'-diallyl-2,4'-dihydroxybiphenyl, 2), were isolated from the stem bark of Magnolia obovata and evaluated for antifungal activity against various human pathogenic fungi. Compound 1 and 2 showed significant inhibitory activities against Trichophyton mentagrophytes, Microsporium gypseum, Epidermophyton floccosum, Aspergillus niger, Cryptococcus neoformans, and Candida albicans with minimum inhibitory concentrations (MIC) in a range of 25-100 microg/ml. Therefore, compound 1 and 2 could be used as lead compounds for the development of novel antifungal agents. |
| Databáze: | OpenAIRE |
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