Female Mice Exposed to Postnatal Neglect Display Angiotensin II–Dependent Obesity‐Induced Hypertension
| Autor: | Carolina Dalmasso, Charles Mark Ensor, Frederique Yiannikouris, Analia S. Loria, Jorge F. Giani, Lisa A. Cassis, Jacqueline R. Leachman |
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| Rok vydání: | 2019 |
| Předmět: |
obesity
medicine.medical_specialty renin‐angiotensin system media_common.quotation_subject Early life stress Adipose tissue Weaning 030204 cardiovascular system & hematology Neglect Mice 03 medical and health sciences 0302 clinical medicine Internal medicine Renin–angiotensin system medicine Animals Original Research media_common Early weaning business.industry Angiotensin II Maternal Deprivation maternal separation medicine.disease Obesity adipose tissue Endocrinology Peripheral Vascular Disease High Blood Pressure Hypertension Female Cardiology and Cardiovascular Medicine business 030217 neurology & neurosurgery |
| Zdroj: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| ISSN: | 2047-9980 |
| DOI: | 10.1161/jaha.119.012309 |
| Popis: | Background We have previously reported that female mice exposed to maternal separation and early weaning (MSEW), a model of early life stress, show exacerbated diet‐induced obesity associated with hypertension. The goal of this study was to test whether MSEW promotes angiotensin II–dependent hypertension via activation of the renin‐angiotensin system in adipose tissue. Methods and Results MSEW was achieved by daily separations from the dam and weaning at postnatal day 17, while normally reared controls were weaned at postnatal day 21. Female controls and MSEW weanlings were placed on a low‐fat diet (LF, 10% kcal from fat) or high‐fat diet (HF, 60% kcal from fat) for 20 weeks. MSEW did not change mean arterial pressure in LF–fed mice but increased it in HF–fed mice compared with controls ( P P P P P Conclusions The upregulation of angiotensinogen and angiotensin II in adipose tissue could be an important mechanism by which female MSEW mice fed a HF develop hypertension. |
| Databáze: | OpenAIRE |
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