Fungal mediated innate immune memory, what have we learned?

Autor: Jessica Quintin
Přispěvatelé: Immunologie des Infections fongiques - immunology of fungal infections, Institut Pasteur [Paris], Institut Carnot Pasteur Maladie Infectieuse ANR-11-CARN-017-01, This work was supported by the ANR JCJC grant [ANR-16-CE15-0014-01] and the Institut Carnot Pasteur MI grant [ANR 11-CARN 017-01] (to J.Q.)., ANR-16-CE15-0014,IIMory,Mémoire immunologique innée des défenses de l'hôte(2016), Institut Pasteur [Paris] (IP)
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
animal diseases
[SDV]Life Sciences [q-bio]
Context (language use)
chemical and pharmacologic phenomena
β-glucan
[SDV.CAN]Life Sciences [q-bio]/Cancer
Disease
Fungal Components
Immunological memory
MESH: Monocytes
Monocytes
03 medical and health sciences
Innate immune memory
0302 clinical medicine
MESH: Mycoses
Immunity
Candida albicans
Humans
[SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology
Immune status
Innate immune system
MESH: Humans
biology
Macrophages
MESH: Candida albicans
Fungi
MESH: Macrophages
Cell Biology
biochemical phenomena
metabolism
and nutrition
biology.organism_classification
Immunity
Innate
3. Good health
030104 developmental biology
[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology
Mycoses
Immunology
MESH: Immunologic Memory
bacteria
[SDV.IMM]Life Sciences [q-bio]/Immunology
MESH: Immunity
Innate
Immunologic Memory
030217 neurology & neurosurgery
Developmental Biology
Zdroj: Seminars in Cell and Developmental Biology
Seminars in Cell and Developmental Biology, Elsevier, 2019, 89, pp.71-77. ⟨10.1016/j.semcdb.2018.05.023⟩
Seminars in Cell and Developmental Biology, 2019, 89, pp.71-77. ⟨10.1016/j.semcdb.2018.05.023⟩
ISSN: 1084-9521
1096-3634
Popis: International audience; The binary classification of mammalian immune memory is now obsolete. Innate immune cells carry memory characteristics. The overall capacity of innate immune cells to remember and alter their responses is referred as innate immune memory and the induction of a non-specific memory resulting in an enhanced immune status is termed "trained immunity". Historically, trained immunity was first described as triggered by the human fungal pathogen Candida albicans. Since, numerous studies have accumulated and deciphered the main characteristics of trained immunity mediated by fungi and fungal components. This review aims at presenting the newly described aspect of memory in innate immunity with an emphasis on the historically fungal mediated one, covering the known molecular mechanisms associated with training. In addition, the review uncovers the numerous non-specific effect that β-glucans trigger in the context of infectious diseases and septicaemia, inflammatory diseases and cancer.
Databáze: OpenAIRE
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