Comparison of DXA, QCT and trabecular structure in beta-thalassaemia
| Autor: | N. Zoumbos, Michalis Leotsinides, Maria Mylona, Theodoros Alexandrides, Panagiotis Dimopoulos |
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| Rok vydání: | 2005 |
| Předmět: |
musculoskeletal diseases
Adult Male High-resolution computed tomography Adolescent Hypoparathyroidism Osteoporosis Lumbar vertebrae Absorptiometry Photon Bone Density medicine Humans Visual estimation Quantitative computed tomography Bone Demineralization Pathologic Dual-energy X-ray absorptiometry Bone mineral medicine.diagnostic_test business.industry Hypogonadism beta-Thalassemia Hematology General Medicine Middle Aged medicine.disease Spine Beta-thalassaemia medicine.anatomical_structure Female business Nuclear medicine Tomography X-Ray Computed |
| Zdroj: | European journal of haematology. 74(5) |
| ISSN: | 0902-4441 |
| Popis: | Osteopathy, as a major feature of homozygous β-thalassaemia, is a multifactorial disorder, not fully understood. We studied the lumbar vertebrae of 48 patients using Dual-Energy X-ray Absorptiometry (DXA) and Quantitative Computed Tomography (QCT), and we focused on structural properties, assessed by High Resolution Computed Tomography (HRCT). Bone Mineral Density (BMD) values were expressed as Z-scores and the results were correlated. The effect of age, sex, and type of thalassaemia and hormonal factors on BMD was assessed. We estimated, with HRCT, the cortex integrity and the number and thickness of trabeculae; the latter were classified to a three-grade scale. Our results showed the overall prevalence of osteoporosis to be 44% with DXA and 6% with QCT. Both techniques revealed an inverse correlation between age and BMD, whereas hormonal factors demonstrated associations with QCT and DXA measurements. The correlation coefficient between DXA's BMD and QCT's trabecular BMD was 0.545 (P |
| Databáze: | OpenAIRE |
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