Energy Transfer across Nonpolar and Polar Contacts in Proteins: Role of Contact Fluctuations
| Autor: | David M. Leitner, Takahisa Yamato, Humanath Poudel, Korey M. Reid |
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| Rok vydání: | 2020 |
| Předmět: |
Quantitative Biology::Biomolecules
Materials science 010304 chemical physics Vibrational energy Hydrogen bond Energy transfer Hydrogen Bonding Molecular Dynamics Simulation 010402 general chemistry Vibration 01 natural sciences 0104 chemical sciences Surfaces Coatings and Films Molecular dynamics symbols.namesake Energy Transfer Chemical physics Villin headpiece 0103 physical sciences Materials Chemistry symbols Polar Orders of magnitude (data) Physical and Theoretical Chemistry van der Waals force |
| Zdroj: | The Journal of Physical Chemistry B. 124:9852-9861 |
| ISSN: | 1520-5207 1520-6106 |
| DOI: | 10.1021/acs.jpcb.0c08091 |
| Popis: | Molecular dynamics simulations of the villin headpiece subdomain HP36 have been carried out to examine relations between rates of vibrational energy transfer across non-covalently bonded contacts and equilibrium structural fluctuations, with focus on van der Waals contacts. Rates of energy transfer across van der Waals contacts vary inversely with the variance of the contact length, with the same constant of proportionality for all nonpolar contacts of HP36. A similar relation is observed for hydrogen bonds, but the proportionality depends on contact pairs, with hydrogen bonds stabilizing the α-helices all exhibiting the same constant of proportionality, one that is distinct from those computed for other polar contacts. Rates of energy transfer across van der Waals contacts are found to be up to 2 orders of magnitude smaller than rates of energy transfer across polar contacts. |
| Databáze: | OpenAIRE |
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