Effects of P50 temporal variability on sensory gating in schizophrenia
| Autor: | Curt A. Sandman, Steven G. Potkin, Yi Jin, Julie V Patterson, William P. Hetrick, William E. Bunney |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Male Psychosis jitter Ensemble averaging Gating Medical and Health Sciences Reference Values Reaction Time medicine Humans Attention Latency (engineering) Evoked potential latency Biological Psychiatry Psychiatry Cerebral Cortex Sensory gating variability P50 Psychology and Cognitive Sciences Classical conditioning Electroencephalography Signal Processing Computer-Assisted medicine.disease schizophrenia Psychiatry and Mental health medicine.anatomical_structure Schizophrenia gating Evoked Potentials Auditory Female Arousal Psychology Neuroscience |
| Zdroj: | Jin, Y; Potkin, SG; Patterson, JV; Sandman, CA; Hetrick, WP; & Bunney, WE. (1997). Effects of P50 temporal variability on sensory gating in schizophrenia.. Psychiatry research, 70(2), 71-81. doi: 10.1016/s0165-1781(97)03091-6. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/0zj5389z |
| ISSN: | 0165-1781 |
| DOI: | 10.1016/s0165-1781(97)03091-6 |
| Popis: | The conditioning-testing (S1-S2) P50 auditory evoked potential (EP) has been well-documented and accepted as an important tool for measuring sensory gating in schizophrenia research. However, the physiological mechanism of the phenomenon is not known. In this study a single-trial analysis was used to determine the influence of the latency variability of the responses in the formation of the averaged P50. Ten schizophrenic patients and 10 normal controls were tested in the dual-click EP paradigm. Using ensemble averaging analysis, we replicated the previous finding of a lower S1 P50 amplitude and higher S2/S1 ratio in schizophrenics compared with normal controls. The single-trial analysis revealed that patients had significantly higher trial-to-trial latency variability in S1 responses than normal subjects, while the S2 showed the same variability as in controls. Measured by the single-trial procedure, the arithmetic mean amplitudes of P50 responses to S1 and S2 were similar between normal and schizophrenic subjects. The same measure also eliminated the difference in averaged P50 amplitude between S1 and S2 for both groups. Temporal variability appears to be an important factor in the assessment of averaged EPs and thus contribute to the change of P50 amplitude observed in schizophrenia. |
| Databáze: | OpenAIRE |
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