Occupational exposure to respirable crystalline silica and chronic non-malignant renal disease: systematic review and meta-analysis
| Autor: | Johannes Gellissen, Matthias Möhner, Anne Pohrt |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Pathology Chronic renal disease Respirable silica Non malignant Disease Review Risk Assessment Cohort Studies 03 medical and health sciences 0302 clinical medicine Glomerulonephritis Silicosis Internal medicine Occupational Exposure medicine Humans 030212 general & internal medicine Renal Insufficiency Chronic Inhalation Exposure Dose-Response Relationship Drug business.industry Public Health Environmental and Occupational Health SMR medicine.disease Silicon Dioxide 030210 environmental & occupational health Occupational Diseases Meta-analysis Case-Control Studies Cohort Occupational exposure business Kidney disease Cohort study |
| Zdroj: | International Archives of Occupational and Environmental Health |
| ISSN: | 1432-1246 0340-0131 |
| Popis: | Background While occupational exposure to respirable silica is known to lead to lung disease, most notably silicosis, its association with chronic kidney disease is unclear. Objectives This review explores the association between occupational exposure to respirable silica and chronic non-malignant renal disease such as glomerulonephritis. The evidence has been collected and compiled. Possible sources of bias are thoroughly discussed. Methods Cohort studies with silica exposure and case–control studies of renal disease were searched in PubMed until January 2015. Two authors independently abstracted data; any disagreement was resolved by consulting a third reviewer. A meta-analysis was performed to evaluate the association to silica exposure. Results A total of 23 cohort and four case–control studies were included in the analysis. The meta-analysis of cohort studies yielded elevated overall SMRs for renal disease. Some studies, however, included dose–response analyses, most of which did not show a positive trend. The approaches and results of the case–control studies were very heterogeneous. Conclusions While the studies of cohorts exposed to silica found elevated SMRs for renal disease, no clear evidence of a dose–response relationship emerged. The elevated risk may be attributed to diagnostic and methodological issues. In order to permit a reliable estimation of a possible causal link, exposed cohorts should be monitored for renal disease, as the information from mortality studies is hardly reliable in this field. Electronic supplementary material The online version of this article (doi:10.1007/s00420-017-1219-x) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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