High fibrinogen-albumin ratio index predicts poor prognosis for lung adenocarcinoma patients undergoing epidermal growth factor receptor-tyrosine kinase inhibitor treatments
| Autor: | Chunhong Hu, Liu Xianling, Na Zhang, Haixia Zhang, Ping Liu, Xiayan Zhao, Jin’an Ma, Tao Hou |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Observational Study Adenocarcinoma of Lung Serum Albumin Human epidermal growth factor receptor-tyrosine kinase inhibitor Fibrinogen fibrinogen-albumin ratio index Gastroenterology 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Internal medicine Carcinoma Non-Small-Cell Lung medicine Carcinoma Humans 030212 general & internal medicine Progression-free survival Neutrophil to lymphocyte ratio Protein Kinase Inhibitors non-small cell lung cancer Univariate analysis business.industry Hazard ratio General Medicine Middle Aged medicine.disease Prognosis Progression-Free Survival Blood Cell Count ErbB Receptors 030220 oncology & carcinogenesis Predictive value of tests Mutation Adenocarcinoma Female business Biomarkers medicine.drug Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 |
| Popis: | Epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKIs) have become the preferred therapy as first-line treatment of non-small cell lung cancer patients harboring sensitizing EGFR mutations. However, the prognostic indicators are limited. The present study aimed to assess the prognostic value of immune-inflammation factors, fibrinogen-albumin ratio index (FARI), neutrophil to lymphocyte ratio (NLR), and platelet to lymphocyte ratio (PLR) in EGFR-Mutant lung adenocarcinoma patients receiving first-generation EGFR-TKIs treatment. 194 patients were included in this retrospective analysis. FARI was calculated as fibrinogen / albumin. Receiver operating characteristic curve was used to evaluate the optimal cut-off value for FARI, NLR, and PLR to progression free survival (PFS). Univariate and multivariate survival analysis were performed to identify factors correlated with PFS and overall survival (OS). Applying cut-offs of ≥0.08 (FARI), ≥3.28 (NLR), and ≥273.85 (PLR), higher FARI or NLR was associated with worse Eastern Cooperative Oncology Group performance status (ECOG PS) (P = .018, .002, respectively), and there were more males in high NLR group (P = .043). In univariate analysis, ECOG PS status, NLR, PLR, and FARI were significantly associated with PFS (P = .017, .004 |
| Databáze: | OpenAIRE |
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