The Impact of Histological Variant on Oncological Outcomes in Patients With Urothelial Carcinoma of the Bladder Treated With Radical Cystectomy
| Autor: | Kenichiro Ikeda, Kenshiro Takemoto, Akio Matsubara, Jun Teishima, Tetsutaro Hayashi, Shogo Inoue, Hirotaka Nagamatsu, Akihiro Goriki, Mitsuru Kajiwara, Yuki Kohada |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Urologic Neoplasms Cancer Research medicine.medical_specialty Squamous Differentiation medicine.medical_treatment Urinary Bladder Urology Kaplan-Meier Estimate Cystectomy Medical Oncology Glandular Differentiation medicine Humans In patient Pathological Proportional Hazards Models Retrospective Studies Urothelial carcinoma Carcinoma Transitional Cell Bladder cancer Proportional hazards model business.industry General Medicine medicine.disease Urinary Bladder Neoplasms Oncology Female business |
| Zdroj: | Anticancer Research. 40:4787-4793 |
| ISSN: | 1791-7530 0250-7005 |
| Popis: | Background/aim Bladder cancer with histological variant (HV) has different morphological features from usual urothelial carcinoma (UC). The aim of this study was to evaluate the oncological outcomes of HV in patients with bladder cancer. Patients and methods We retrospectively evaluated data from 102 patients with UC of the bladder treated with radical cystectomy between 1998 and 2017. Pathological findings including HV were assigned by one dedicated pathologist. Recurrence-free survival (RFS) and cancer-specific survival (CSS) and overall survival (OS) were estimated by Cox regression models. Results In total, 26 patients (25.5%) had HV, and the most common variant was squamous differentiation, followed by glandular differentiation and a mixed variant consisted of squamous and glandular differentiation. The presence of HV was associated with RFS and CSS (p=0.018, p=0.036, respectively). Conclusion HV has more aggressive tumor biological features compared to those with pure UC. The presence of HV was associated with poor survival. |
| Databáze: | OpenAIRE |
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