Hyporeninemic hypoaldosteronism in diabetic patients with chronic renal failure
| Autor: | J. M. Tabernero Romo, J. Grande Villoria, J.M. Miralles, S. De Castro del Pozo, J. F. Macías Núñez |
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| Rok vydání: | 1988 |
| Předmět: |
Adult
Male medicine.medical_specialty Renal function Plasma renin activity Kidney Concentrating Ability Renin-Angiotensin System chemistry.chemical_compound Internal medicine Diabetes mellitus Renin–angiotensin system medicine Humans Diabetic Nephropathies Acidosis Aged Aldosterone business.industry Hyporeninemic hypoaldosteronism Acidosis Renal Tubular Middle Aged medicine.disease Hypoaldosteronism Endocrinology Diabetes Mellitus Type 1 chemistry Nephrology Kidney Failure Chronic Female medicine.symptom business Glomerular Filtration Rate |
| Zdroj: | American journal of nephrology. 8(2) |
| ISSN: | 0250-8095 |
| Popis: | Plasma renin activity, plasma aldosterone levels and renal tubular capacity to excrete hydrogen ions were studied in 13 patients suffering from diabetes mellitus with a creatinine clearance of less than 40 ml/min. The results were compared with those obtained in a control group, in a group of nondiabetic subjects with chronic renal failure (CRF) and in a group of diabetic patients without CRF. Twelve of the thirteen diabetic patients with CRF had data characteristic of hyporeninemic hypoaldosteronism associated with type IV renal tubular acidosis. On comparing the results with those of the other two groups of patients, it was observed that the manifestations of the latter two groups considered separately were different from those of the problem group, although in the diabetic patients with normal glomerular filtration rate (GFR) hyporeninism but not hypoaldosteronism was present accompanied by a lower net acid excretion (p less than 0.001) due to a lower excretion of NH4 (p less than 0.05) and titratable acid (p less than 0.001) when the patients were challenged with an NH4Cl overload. We believe that a conjunction of diabetes and renal failure is necessary for the diabetic patients with a decrease in GFR to show hyporeninemic hypoaldosteronism and type IV tubular acidosis. |
| Databáze: | OpenAIRE |
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