Fetal hemodynamics and language skills in primary school-aged children with fetal growth restriction : A longitudinal study
| Autor: | Kaarin Mäkikallio, Anneli Yliherva, Noora Korkalainen, Juha Rasanen, Lea Partanen |
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| Přispěvatelé: | Department of Obstetrics and Gynecology, HUS Gynecology and Obstetrics, University of Helsinki |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Longitudinal study Pediatrics Hemodynamics Literacy Umbilical Arteries READING FLUENCY UMBILICAL ARTERY 0302 clinical medicine Pregnancy 3123 Gynaecology and paediatrics FOR-GESTATIONAL-AGE Longitudinal Studies Child media_common Fetal Growth Retardation 4. Education Fetal growth restriction Obstetrics and Gynecology Gestational age Brain REFERENCE RANGES Vasodilation DOPPLER RATIO Female medicine.medical_specialty media_common.quotation_subject education Cerebroplacental ratio PRETERM CHILDREN Placental insufficiency TERM Language Development Ultrasonography Prenatal 03 medical and health sciences PULSATILITY INDEX 030225 pediatrics medicine.artery medicine Humans Placental Circulation BLOOD-FLOW business.industry Infant Newborn Umbilical artery Odds ratio VELOCITY medicine.disease Long-term outcome Pediatrics Perinatology and Child Health Language skills business Neurocognitive 030217 neurology & neurosurgery |
| Popis: | Aim: Long-term follow-up studies on children born with fetal growth restriction (FGR) have revealed a specific profile of neurocognitive difficulties, including problems with speech, language and literacy skills. We hypothesized that problems with communication skills, including language use and literacy skills of FGR children at primary school age are associated with prenatal circulatory changes. Methods: Ultrasonographic assessment of fetoplacental hemodynamics was performed prenatally in 77 fetuses. After a follow-up period of 8–10 years, assessment of reading and spelling skills using standardized tests and the Children‘s Communication Questionnaire (CCC-2) was performed to measure different language skills in 37 FGR children and 31 appropriately grown (AGA) controls, matched for gestational age. Results: Increased blood flow resistance in the umbilical artery (UA PI > 2 SD) during fetal life showed odds ratios of 3.5–19.1 for poor literacy and communication skills and need for speech and language therapy. Furthermore, FGR children with prenatal cerebral vasodilatation (cerebroplacental ratio (CPR) |
| Databáze: | OpenAIRE |
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