Hemodynamic effects of a prostacyclin analog (iloprost) on portal flow velocity and volume and visceral artery circulation in patients with lower limb arteriopathy
Autor: | Aldo Dobrina, Antonio Picardi, Giovanni Ambrosino, Sebastiano Costantino, Enrico Maria Zardi, Angelo Serio |
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Přispěvatelé: | Zardi, Em, Picardi, A, Ambrosino, G, Serio, A, Costantino, S, Dobrina, Aldo |
Rok vydání: | 2003 |
Předmět: |
Male
Duplex ultrasonography Acoustics and Ultrasonics Vasodilator Agents Hemodynamics Prostacyclin Hepatic Artery Renal Artery Medicine Portal flow velocity and volume Ultrasonography Doppler Color Portal hypertension Mesenteric arteries Peripheral Vascular Diseases Blood Volume Radiological and Ultrasound Technology Portal Vein Arterial resistance index Middle Aged musculoskeletal system medicine.anatomical_structure Interlobar renal artery cardiovascular system Cardiology lipids (amino acids peptides and proteins) Female Radiology Color Doppler ultrasound circulatory and respiratory physiology medicine.drug Adult medicine.medical_specialty Biophysics Microcirculation Mesenteric Artery Superior Internal medicine Iloprost Humans Radiology Nuclear Medicine and imaging Aged business.industry Vascular disease medicine.disease Regional Blood Flow Case-Control Studies Vascular Resistance business |
Zdroj: | Ultrasound in medicinebiology. 29(2) |
ISSN: | 0301-5629 |
Popis: | —Previous studies demonstrated that iloprost improves the peripheral circulation. In this study, we examined, by Doppler sonography, portal flow velocity (cm/s) and volume (mL/min), and resistance index (RI) of visceral arteries in 23 patients before and after 7 days of iloprost infusion. Statistically significant hemodynamic changes were only seen in portal vein (pre-iloprost vs. post-iloprost treatment mean portal flow velocity and volume values: 23.9 cm/s vs. 29.0 cm/s, p < 0.001 and 1824.6 mL/min vs. 2294.4 mL/min, p < 0.001, respectively). On the other hand, the interlobar renal artery RI, reduced after iloprost treatment in most patients, was not statistically significant; conflicting results were obtained on the hepatic and mesenteric arteries. Our results indicate that iloprost significantly increases portal flow velocity and volume. The understanding of the mechanism through which iloprost plays a role in portal microcirculation could be useful for its new medical indications in liver hemodynamic disorders. Ultrasound in Medicine & Biology. |
Databáze: | OpenAIRE |
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