Hemodynamic effects of a prostacyclin analog (iloprost) on portal flow velocity and volume and visceral artery circulation in patients with lower limb arteriopathy

Autor: Aldo Dobrina, Antonio Picardi, Giovanni Ambrosino, Sebastiano Costantino, Enrico Maria Zardi, Angelo Serio
Přispěvatelé: Zardi, Em, Picardi, A, Ambrosino, G, Serio, A, Costantino, S, Dobrina, Aldo
Rok vydání: 2003
Předmět:
Male
Duplex ultrasonography
Acoustics and Ultrasonics
Vasodilator Agents
Hemodynamics
Prostacyclin
Hepatic Artery
Renal Artery
Medicine
Portal flow velocity and volume
Ultrasonography
Doppler
Color
Portal hypertension
Mesenteric arteries
Peripheral Vascular Diseases
Blood Volume
Radiological and Ultrasound Technology
Portal Vein
Arterial resistance index
Middle Aged
musculoskeletal system
medicine.anatomical_structure
Interlobar renal artery
cardiovascular system
Cardiology
lipids (amino acids
peptides
and proteins)
Female
Radiology
Color Doppler ultrasound
circulatory and respiratory physiology
medicine.drug
Adult
medicine.medical_specialty
Biophysics
Microcirculation
Mesenteric Artery
Superior
Internal medicine
Iloprost
Humans
Radiology
Nuclear Medicine and imaging
Aged
business.industry
Vascular disease
medicine.disease
Regional Blood Flow
Case-Control Studies
Vascular Resistance
business
Zdroj: Ultrasound in medicinebiology. 29(2)
ISSN: 0301-5629
Popis: —Previous studies demonstrated that iloprost improves the peripheral circulation. In this study, we examined, by Doppler sonography, portal flow velocity (cm/s) and volume (mL/min), and resistance index (RI) of visceral arteries in 23 patients before and after 7 days of iloprost infusion. Statistically significant hemodynamic changes were only seen in portal vein (pre-iloprost vs. post-iloprost treatment mean portal flow velocity and volume values: 23.9 cm/s vs. 29.0 cm/s, p < 0.001 and 1824.6 mL/min vs. 2294.4 mL/min, p < 0.001, respectively). On the other hand, the interlobar renal artery RI, reduced after iloprost treatment in most patients, was not statistically significant; conflicting results were obtained on the hepatic and mesenteric arteries. Our results indicate that iloprost significantly increases portal flow velocity and volume. The understanding of the mechanism through which iloprost plays a role in portal microcirculation could be useful for its new medical indications in liver hemodynamic disorders. Ultrasound in Medicine & Biology.
Databáze: OpenAIRE
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