Role of mitochondrial dysfunction on rheumatic diseases
| Autor: | M J López-Armada, Carlos Vaamonde-García |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cell physiology Programmed cell death Oxidative phosphorylation Mitochondrion medicine.disease_cause Biochemistry 03 medical and health sciences 0302 clinical medicine Rheumatic Diseases NLR Family Pyrin Domain-Containing 3 Protein medicine Animals Homeostasis Humans Inflammation Pharmacology business.industry Immunity Inflammasome Acquired immune system Mitochondria Cell biology 030104 developmental biology 030220 oncology & carcinogenesis Signal transduction business Oxidative stress Signal Transduction medicine.drug |
| Zdroj: | Biochemical Pharmacology. 165:181-195 |
| ISSN: | 0006-2952 |
| DOI: | 10.1016/j.bcp.2019.03.008 |
| Popis: | Rheumatic and musculoskeletal diseases are a heterogeneous group of disorders affecting joint tissues and in some cases even organs, some of them being among the most common diseases worldwide. Mitochondria are the organelles considered as powerhouse of cells providing energy to the organism mainly through oxidative phosphorylation. However, mitochondria are also involved in crucial pathways responsible for maintaining cell physiology, such as the activation of metabolic and survival signaling, and innate and adaptive immune response. As consequence of the pivotal role of mitochondria in cell homeostasis, an impairment of mitochondrial function has been associated with activation of pathological events, including oxidative stress and subsequently damaged protein and DNA, deregulation of programmed cell death, and over-activation of inflammatory responses modulated by redox-sensitive signaling or direct activation of the inflammasome. Thus, a growing amount of evidence emphasizes the role of mitochondria in aging and inflammatory-related diseases, including rheumatic disorders. In this regard, emerging findings suggest that targeting of the pathways involved in the maintenance of mitochondrial metabolism may control cell homeostasis, and in turn delay ageing and prevent or improve articular pathologies. In this review we will focus on the importance of mitochondria in metabolic homeostasis of articular cells, as well as their influence on the activation of pathological signaling pathways, as a result of a genetic predisposition, damage, decline or impairment of their function. Finally, we will discuss some of the most important evidences of involvement of mitochondria in the onset and progression of rheumatic diseases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect