Direct and Selective Modification of RNA - An Open Challenge in Nucleic Acid Chemistry
| Autor: | Dennis Gillingham, Dnyaneshwar B. Rasale |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Bioorthogonal reporters Rna therapeutics Transcription Genetic Chemistry Rna chemistry Bioconjugation RNA General Medicine General Chemistry Computational biology 03 medical and health sciences 030104 developmental biology Nucleic acid chemistry Transcription (biology) RNA modification RNA Messenger QD1-999 Solid-Phase Synthesis Techniques Nucleic acid therapeutics |
| Zdroj: | CHIMIA, Vol 72, Iss 11 (2018) |
| ISSN: | 0009-4293 |
| Popis: | We present the state-of-the-art in direct RNA modification as well as the challenges that hold back further development of RNA mechanistic probes and medicines. Solid-phase synthesis has revolutionized the synthesis of short DNAs and RNAs. Many open questions in RNA biology are with large long-non-coding RNAs or mRNAs and there is also interest in developing these big RNAs as medicines. Techniques for direct modification will become more important in the coming years and we give a current snapshot of the field here, with a bias towards our own contributions. |
| Databáze: | OpenAIRE |
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