Cytokines and growth factors in a biologic product obtained from patients' urine as immune-modulators to treat autoimmune and allergic diseases
| Autor: | L.F. Miranda de la Cruz, A. Fragoso-Sánchez, M.L. Pedraza-Jiménez, S. Hernández-Doño, M. García-Rivas, J. Granados, M.L. Ceja-Mendoza, José Eduardo Márquez-García, L. Martínez-Escobar |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male 0301 basic medicine Eotaxin medicine.medical_treatment Immunology Urine Fibroblast growth factor Biochemistry Autoimmune Diseases 03 medical and health sciences 0302 clinical medicine Immune system Hypersensitivity medicine Humans Immunology and Allergy Molecular Biology Aged Autoimmune disease business.industry Growth factor Hematology Middle Aged medicine.disease 030104 developmental biology Cytokine 030220 oncology & carcinogenesis Chronic Disease Cytokines Female Personalized medicine business |
| Zdroj: | Cytokine. 141:155427 |
| ISSN: | 1043-4666 |
| DOI: | 10.1016/j.cyto.2021.155427 |
| Popis: | At "Instituto de Alergias y Autoinmunidad Dr. Maximiliano Ruiz Castaneda, A.C." in Mexico City, a non-traditional health care center focused on the treatment of autoimmune and allergic diseases using personalized medicine, an alternative treatment referred to as an "immune-modulator" has been developed. In this study, we will refer to this treatment substance as the "immune-modulator." In brief, a urine sample is collected from the patient and processed to obtain the peptide fraction, which is conditioned and then administered sublingually to the patient. Sample processing involves multiple steps aimed at the removal of toxic compounds and enrichment for cytokines, growth factors, and other immune peptides that may contribute to the function of the immune-modulator. This treatment has been administered for many years, and patients testify that it is useful and reliable. Despite the benefits of this treatment, the molecular mechanisms underlying its effects have not been thoroughly investigated. Therefore, this study aims to identify immunoregulatory peptides, such as cytokines and growth factors, in the immune-modulator. Urine and immune-modulator concentrations of cytokines and growth factors were assessed using a Luminex assay. Twenty-one cytokines and growth factors were identified in immune-modulator samples. MCP-1 was identified in 100% of the samples; MIP-1β, IL-8, RANTES, INF-γ, and IP-10 were identified in approximately 65-70% of samples; IL5, IL-1B, and IL-17 in 50-60%; eotaxin, VEGF, IL-6, and FGF in about 40%; MIP-1α, IL-9, GM-CSF, G-CSF, IL-12, and IL-15 in about 20-30%; and IL-13 and PDGF-bb were identified in |
| Databáze: | OpenAIRE |
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