Arf proteins in cancer cell migration
| Autor: | Alexandra Faustino, Cristina Casalou, Duarte C. Barral |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Cytoskeleton organization cell migration media_common.quotation_subject Integrin small GTP-binding proteins actin cytoskeleton remodeling integrin recycling Biochemistry 03 medical and health sciences Cell Movement Neoplasms medicine Humans Neoplasm Metastasis Cell adhesion Internalization Cytoskeleton media_common biology ADP-Ribosylation Factors Cell Membrane Cancer Arf Cell migration cell adhesion Cell Biology medicine.disease Actins Cell biology Gene Expression Regulation Neoplastic Protein Transport 030104 developmental biology Cancer cell Arl biology.protein Commentary Guanine nucleotide exchange factor |
| Zdroj: | Small GTPases |
| ISSN: | 2154-1256 |
| Popis: | Members of the ADP-ribosylation factor (Arf) family of small GTP-binding (G) proteins regulate several aspects of membrane trafficking, such as vesicle budding, tethering and cytoskeleton organization. Arf family members, including Arf-like (Arl) proteins have been implicated in several essential cellular functions, like cell spreading and migration. These functions are used by cancer cells to disseminate and invade the tissues surrounding the primary tumor, leading to the formation of metastases. Indeed, Arf and Arl proteins, as well as their guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs) have been found to be abnormally expressed in different cancer cell types and human cancers. Here, we review the current evidence supporting the involvement of Arf family proteins and their GEFs and GAPs in cancer progression, focusing on 3 different mechanisms: cell-cell adhesion, integrin internalization and recycling, and actin cytoskeleton remodeling. |
| Databáze: | OpenAIRE |
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