Voatriafricanines A and B, Trimeric Vobasine-Aspidosperma-Aspidosperma Alkaloids from Voacanga africana
| Autor: | Jérôme Vanheuverzwijn, Franck Meyer, Augustin Ephrem Nkengfack, Véronique Fontaine, Jean-François Gallard, Pierre Le Pogam, Erwan Poupon, Mehdi A. Beniddir, Karine Leblanc, Pierre Mkounga, Zhiyu Zhou, Somia Rharrabti, Hugues Fouotsa, Guillaume Bernadat, Alain Meli Lannang |
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| Přispěvatelé: | Biomolécules : Conception, Isolement, Synthèse (BioCIS), Institut de Chimie du CNRS (INC)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-CY Cergy Paris Université (CY), Université de Yaoundé I - UY1 (CAMEROON), Institut de Chimie des Substances Naturelles (ICSN), Institut de Chimie du CNRS (INC)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Transfrontalière BioEcoAgro - UMR 1158 (BioEcoAgro), Université d'Artois (UA)-Université de Liège-Université de Picardie Jules Verne (UPJV)-Université du Littoral Côte d'Opale (ULCO)-Université de Lille-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), Faculté de Pharmacie [Bruxelles] (ULB), Université libre de Bruxelles (ULB) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.drug_class
Stereochemistry Monoterpene MESH: Molecular Structure Pharmaceutical Science MESH: Voacanga 010402 general chemistry Antimycobacterial 01 natural sciences Homonuclear molecule Analytical Chemistry MESH: Anti-Bacterial Agents Immunologie Drug Discovery medicine [CHIM]Chemical Sciences MESH: Phytochemicals Pharmacology biology 010405 organic chemistry Hydrogen bond Chemistry Organic Chemistry Biologie moléculaire MESH: Cameroon biology.organism_classification 0104 chemical sciences MESH: Indole Alkaloids Voacanga africana Complementary and alternative medicine Heteronuclear molecule Intramolecular force Aspidosperma Molecular Medicine Biologie cellulaire Microbiologie et protistologie [bacteriol.virolog.mycolog.] MESH: Plant Bark |
| Zdroj: | Journal of Natural Products Journal of Natural Products, 2021, 84 (10), pp.2755-2761. ⟨10.1021/acs.jnatprod.1c00812⟩ Journal of natural products |
| ISSN: | 0163-3864 1520-6025 |
| DOI: | 10.1021/acs.jnatprod.1c00812⟩ |
| Popis: | International audience; Voatriafricanines A and B (1 and 2), the first examples of vobasine-aspidosperma-aspidosperma monoterpene trisindole alkaloids, were isolated from the stem barks of Voacanga africana, guided by a molecular networking strategy. Their structures, including absolute configurations, were elucidated by spectroscopic methods and ECD calculations. Compounds 1 and 2 possess intramolecular hydrogen bonding, sufficiently robust to transfer homonuclear and heteronuclear magnetizations. Compound 1 exhibited potent antimycobacterial activity with no discernible cytotoxic activity. |
| Databáze: | OpenAIRE |
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