The vesicular stomatitis virus-based Ebola virus vaccine: From concept to clinical trials
| Autor: | Andrea Marzi, Ellen Suder, Emmie de Wit, Wakako Furuyama, Heinz Feldmann |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
filovirus
0301 basic medicine Drug-Related Side Effects and Adverse Reactions viruses Immunology Drug Evaluation Preclinical Review Vaccines Attenuated medicine.disease_cause West africa 03 medical and health sciences 0302 clinical medicine Animals Humans Immunology and Allergy Medicine 030212 general & internal medicine Ebola Vaccines Pharmacology Clinical Trials as Topic Drug Carriers Vaccines Synthetic clinical trials Ebola virus biology business.industry Vesiculovirus Hemorrhagic Fever Ebola biology.organism_classification Virology animal models Clinical trial 030104 developmental biology phase 1 phase 2 Preclinical testing Vesicular stomatitis virus phase 3 VSV-EBOV preclinical testing business |
| Zdroj: | Human Vaccines & Immunotherapeutics |
| ISSN: | 2164-554X 2164-5515 |
| DOI: | 10.1080/21645515.2018.1473698 |
| Popis: | The devastating Ebola virus (EBOV) epidemic in West Africa in 2013–2016 accelerated the progress of several vaccines and antivirals through clinical trials, including the replication-competent vesicular stomatitis virus-based vaccine expressing the EBOV glycoprotein (VSV-EBOV). Extensive preclinical testing in animal models demonstrated the prophylactic and post-exposure efficacy of this vaccine, identified the mechanism of protection, and suggested it was safe for human use. Based on these data, VSV-EBOV was extensively tested in phase 1–3 clinical trials in North America, Europe and Africa. Although some side effects of vaccination were observed, these clinical trials showed that the VSV-EBOV was safe and immunogenic in humans. Moreover, the data supported the use of VSV-EBOV as an emergency vaccine in individuals at risk for Ebola virus disease. In this review, we summarize the results of the extensive preclinical and clinical testing of the VSV-EBOV vaccine. |
| Databáze: | OpenAIRE |
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