Neutralization of Typhoid Toxin by Alpaca-Derived, Single-Domain Antibodies Targeting the PltB and CdtB Subunits

Autor:	Hari P. Dulal, David J. Vance, Durga P. Neupane, Xiangcheng Chen, Jacqueline M. Tremblay, Charles B. Shoemaker, Nicholas J. Mantis, Jeongmin Song
Rok vydání:	2022
Předmět:	Immunology Endothelial Cells Salmonella typhi Single-Domain Antibodies bacterial infections and mycoses complex mixtures Microbiology Mice Infectious Diseases Polysaccharides Animals Parasitology Typhoid Fever Camelids New World
Zdroj:	Infection and Immunity. 90
ISSN:	1098-5522 0019-9567
DOI:	10.1128/iai.00515-21
Popis:	Typhoid toxin is secreted by the typhoid fever-causing bacterial pathogen Salmonella enterica serovar Typhi and has tropism for immune cells and brain endothelial cells. Here, we generated a camelid single-domain antibody (VHH) library from typhoid toxoid-immunized alpacas and identified 41 VHHs selected on the glycan receptor-binding PltB and nuclease CdtB.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa936fa7a70b652185e778ed215be157 https://doi.org/10.1128/iai.00515-21 Zobrazit plný text záznamu