Topical application of cashew gum or chlorhexidine gel reduces overexpression of proinflammatory genes in experimental periodontitis
| Autor: | Hygor Ferreira-Fernandes, Marcos Aurélio L. Barros, Manoel D. Souza Filho, Jand Venes R. Medeiros, Daniel Fernando P. Vasconcelos, Durcilene A. Silva, Ana Carolina M. Leódido, Felipe Rodolfo P. Silva, Luiz Felipe C. França, David Di Lenardo, France Keiko N. Yoshioka, Juan Antonio Rey, Rommel R. Burbano, Giovanny R. Pinto |
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| Rok vydání: | 2019 |
| Předmět: |
Transcription
Genetic Administration Topical Inflammation Pharmacology Polysaccharide Biochemistry Proinflammatory cytokine Structural Biology Plant Gums Gene expression medicine Animals Anacardium Rats Wistar Periodontitis Molecular Biology chemistry.chemical_classification biology business.industry Chlorhexidine General Medicine Periodontium biology.organism_classification medicine.disease Rats Gene Expression Regulation chemistry Female medicine.symptom business Gels medicine.drug |
| Zdroj: | International Journal of Biological Macromolecules. 128:934-940 |
| ISSN: | 0141-8130 |
| Popis: | This study aimed to explore the effect of topically administering an orabase gel containing cashew gum (CG), a complex polysaccharide from Anacardium occidentale L., on the transcription of important proinflammatory (COX-2, NOS-2, INF-γ, OSCAR, and MYD88) and anti-inflammatory genes (IL-10, IL-4, and TGFβ1) in the gingival tissues of rats with ligature-induced periodontitis, compared to the effect observed upon topically applying a well-known antibiofilm agent (chlorhexidine) under the same experimental conditions. The gene expression profile in the gingival tissues of rats with periodontitis treated with CG did not statistically significantly differ from that observed in the group of animals treated with chlorhexidine. Results showed that CG is able to attenuate general inflammation in the periodontium by reducing the transcription of proinflammatory mediators in a MYD88-independent manner, and not by inducing the expression of anti-inflammatory factors. In conclusion, this study demonstrated that CG and chlorhexidine treatment reduced significantly the gene overexpression (COX-2, NOS-2, INF-γ, OSCAR, and TGFβ1) in the model of ligature-induced periodontitis. |
| Databáze: | OpenAIRE |
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