Typical and Atypical Inducers of Lysosomal Cell Death: A Promising Anticancer Strategy
| Autor: | Malgorzata Bobrowicz, Malgorzata Firczuk, Antoni Domagala, Kacper Szczygiel, Joanna Stachura, Klaudyna Fidyt |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Programmed cell death autophagy Antineoplastic Agents Review lysosomotropic agents Catalysis Malignant transformation lcsh:Chemistry Inorganic Chemistry 03 medical and health sciences 0302 clinical medicine lysosomes Lysosome Neoplasms medicine Animals Humans lysosomal membrane permeabilization Physical and Theoretical Chemistry lcsh:QH301-705.5 Molecular Biology Spectroscopy drug resistance Cell Death Chemistry Kinase Organic Chemistry Autophagy apoptosis General Medicine 3. Good health Computer Science Applications Cell biology 030104 developmental biology medicine.anatomical_structure lcsh:Biology (General) lcsh:QD1-999 Mechanism of action Photochemotherapy Apoptosis 030220 oncology & carcinogenesis Cancer cell medicine.symptom |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 19, Iss 8, p 2256 (2018) |
| ISSN: | 1422-0067 |
| Popis: | Lysosomes are conservative organelles with an indispensable role in cellular degradation and the recycling of macromolecules. However, in light of recent findings, it has emerged that the role of lysosomes in cancer cells extends far beyond cellular catabolism and includes a variety of cellular pathways, such as proliferation, metastatic potential, and drug resistance. It has been well described that malignant transformation leads to alterations in lysosomal structure and function, which, paradoxically, renders cancer cells more sensitive to lysosomal destabilization. Furthermore, lysosomes are implicated in the regulation and execution of cell death in response to diverse stimuli and it has been shown that lysosome-dependent cell death can be utilized to overcome apoptosis and drug resistance. Thus, the purpose of this review is to characterize the role of lysosome in cancer therapy and to describe how these organelles impact treatment resistance. We summarized the characteristics of typical inducers of lysosomal cell death, which exert its function primarily via alterations in the lysosomal compartment. The review also presents other anticancer agents with the predominant mechanism of action different from lysosomal destabilization, the activity of which is influenced by lysosomal signaling, including classical chemotherapeutics, kinase inhibitors, monoclonal antibodies, as well as photodynamic therapy. |
| Databáze: | OpenAIRE |
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