Evaluation of the effect of Toxocara cati infection in the mouse model of allergic asthma: Exacerbation of allergic asthma symptoms and Th2 types of response
| Autor: | Alireza Haghparast, Mohsen Maleki, Hassan Borji, Sima Parandeh Shirvan, Amin Bakhshani |
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| Rok vydání: | 2019 |
| Předmět: |
Allergy
Exacerbation 040301 veterinary sciences 030231 tropical medicine Immunology Immunoglobulin E Microbiology 0403 veterinary science 03 medical and health sciences Toxocara cati 0302 clinical medicine medicine Immunology and Allergy Eosinophilia Asthma General Veterinary biology medicine.diagnostic_test 04 agricultural and veterinary sciences General Medicine respiratory system Eosinophil medicine.disease biology.organism_classification respiratory tract diseases Infectious Diseases Bronchoalveolar lavage medicine.anatomical_structure biology.protein medicine.symptom |
| Zdroj: | Comparative immunology, microbiology and infectious diseases. 71 |
| ISSN: | 1878-1667 |
| Popis: | Toxocariasis is considered a neglected disease despite the importance of Toxocara spp. infections for human health and is little recognized as a significant problem by public health institutions in developing countries. Epidemiological studies suggest that infection with Toxocara cati contributes to the development of allergic asthma.In the present study, we investigated the effect of T. cati infection on experimental allergic airway inflammation using murine model. BALB/c mice were infected by oral administration with 500 embryonated T. cati eggs followed by ovalbumin (OVA) sensitization and challenge to induce allergic airway inflammation. Infection with T. cati in combination with OVA treatment leads to exacerbation of pulmonary inflammation, eosinophilia, airway hyperresponsiveness, OVA specific IgE. Cytokines measurement in bronchoalveolar lavage indicated that the levels of IL-4 and IL-5 in BAL fluid significantly increased after T. cati infected, OVA treated or a combination of both. Increased level of IL-5 was measured in the lungs of T. cati-infected or OVA-treated mice compared with controls. Moreover, combining infection and OVA treatment significantly increase the level of these cytokines. A direct association between T. cati infection and asthma was found in murine model. Although a wide range of helminth species have been demonstrated to modulate allergic responses, most notably the intestinal nematode T. cati, increases airway hyperresponsiveness, lung histopathology, eosinophil recruitment, and Th2 cytokines in alum-sensitized models of airway allergy. |
| Databáze: | OpenAIRE |
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