Effect of Pachybasin on General Toxicity and Developmental Toxicity in Vivo
| Autor: | Shu-Ying Liu, Ming-Huan Chan, Huan-Lin Peng, Yi-Ruu Lin, Kou-Cheng Peng |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Developmental toxicity Secondary Metabolism Anthraquinones Pharmacology Secondary metabolite Motor Activity 03 medical and health sciences Mice 0302 clinical medicine In vivo medicine Animals Zebrafish Trichoderma Kidney biology General Chemistry biology.organism_classification Motor coordination Fungicides Industrial 030104 developmental biology Nociception medicine.anatomical_structure Larva Toxicity General Agricultural and Biological Sciences 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Journal of agricultural and food chemistry. 65(48) |
| ISSN: | 1520-5118 |
| Popis: | To document the safety of pachybasin, a secondary metabolite of Trichoderma harzianum, for use as a bioagricultural agent, it was subjected to general toxicological testing in mice and developmental toxicity in zebrafish. With either 5 or 20 mg kg–1 pachybasin i.p. injection, mice behavioral responses such as motor coordination, spontaneous locomotor activity, or nociceptive pain were not influenced. In long-term effect (daily injection for 14 days), the physiological, hematological, liver, and kidney functions were not altered either. Evidence for the developmental toxicity of pachybasin (10–100 μM) in 72-h exposure period was shown in zebrafish larvae, based on developmental retardation, impairment of chorion, and increase of mortality. In summary, there are no significant general toxicities presented in the pachybasin-treated adult male mice. However, the embryo-toxicity in aquatic biota should be taken into consideration during bioagricultural agent application. |
| Databáze: | OpenAIRE |
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