Morbid Obesity as a Risk Factor for Hospitalization and Death Due to 2009 Pandemic Influenza A(H1N1) Disease
| Autor: | Oliver Morgan, Anthony E. Fiore, Thomas H. Taylor, Chad L. Cox, Seema Jain, Laurie Kamimoto, Sonja J. Olsen, Lyn Finelli, Anna M. Bramley, David S. Freedman, Ashley Fowlkes, Paul Gargiullo, Alicia M. Fry, Brook Belay |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Infectious Diseases/Epidemiology and Control of Infectious Diseases
Adult Male Pediatrics medicine.medical_specialty Adolescent National Health and Nutrition Examination Survey Population Public Health and Epidemiology lcsh:Medicine Public Health and Epidemiology/Infectious Diseases Comorbidity Overweight Childhood obesity Body Mass Index Cohort Studies Influenza A Virus H1N1 Subtype Risk Factors Influenza Human Humans Medicine Risk factor lcsh:Science Child education Pandemics education.field_of_study Multidisciplinary business.industry lcsh:R Infant Odds ratio medicine.disease Obesity Morbid Hospitalization Child Preschool Immunology Cohort lcsh:Q Female medicine.symptom business Body mass index Research Article |
| Zdroj: | PLoS ONE PLoS ONE, Vol 5, Iss 3, p e9694 (2010) |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0009694 |
| Popis: | BACKGROUND: Severe illness due to 2009 pandemic A(H1N1) infection has been reported among persons who are obese or morbidly obese. We assessed whether obesity is a risk factor for hospitalization and death due to 2009 pandemic influenza A(H1N1), independent of chronic medical conditions considered by the Advisory Committee on Immunization Practices (ACIP) to increase the risk of influenza-related complications. METHODOLOGY/PRINCIPAL FINDINGS: We used a case-cohort design to compare cases of hospitalizations and deaths from 2009 pandemic A(H1N1) influenza occurring between April-July, 2009, with a cohort of the U.S. population estimated from the 2003-2006 National Health and Nutrition Examination Survey (NHANES); pregnant women and children or=20 year olds, hospitalization was associated with being morbidly obese (BMI>or=40) for individuals with ACIP-recognized chronic conditions (OR = 4.9, 95% CI 2.4-9.9) and without ACIP-recognized chronic conditions (OR = 4.7, 95%CI 1.3-17.2). Among 2-19 year olds, hospitalization was associated with being underweight (BMIor=20 years without ACIP-recognized chronic medical conditions death was associated with obesity (OR = 3.1, 95%CI: 1.5-6.6) and morbid obesity (OR = 7.6, 95%CI 2.1-27.9). CONCLUSIONS/SIGNIFICANCE: Our findings support observations that morbid obesity may be associated with hospitalization and possibly death due to 2009 pandemic H1N1 infection. These complications could be prevented by early antiviral therapy and vaccination. |
| Databáze: | OpenAIRE |
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