Mapping of a Gene for Parkinson's Disease to Chromosome 4q21-q23
| Autor: | G. Sanges, Roger C. Duvoisin, Lana T. Pho, Alejandro A. Schäffer, Giuseppe Di Iorio, Lawrence I. Golbe, William G. Johnson, Edward S. Stenroos, Robert L. Nussbaum, Alice M. Lazzarini, J. J. Higgins, Susan E. Ide, Mihael H. Polymeropoulos |
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| Rok vydání: | 1996 |
| Předmět: |
Genetic Markers
Male Parkinson's disease Genetic Linkage Population Disease Biology Degenerative disease Gene mapping Genetic linkage medicine Humans education Genetics education.field_of_study Multidisciplinary Chromosome Mapping Family aggregation Parkinson Disease medicine.disease Pedigree Phenotype Genetic marker Female Chromosomes Human Pair 4 Lod Score |
| Zdroj: | Science. 274:1197-1199 |
| ISSN: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.274.5290.1197 |
| Popis: | Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease, affecting approximately 1 percent of the population over age 50. Recent studies have confirmed significant familial aggregation of PD and a large number of large multicase families have been documented. Genetic markers on chromosome 4q21-q23 were found to be linked to the PD phenotype in a large kindred with autosomal dominant PD, with a Zmax = 6.00 for marker D4S2380. This finding will facilitate identification of the gene and research on the pathogenesis of PD. |
| Databáze: | OpenAIRE |
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