Anti-myelin oligodendrocyte glycoprotein (MOG) antibodies in patients with optic neuritis and seizures
| Autor: | Ilya Kister, Steven Galetta, Mark J. Kupersmith, Josef Maxwell Gutman |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Male Optic Neuritis Central nervous system Antibodies Myelin oligodendrocyte glycoprotein 03 medical and health sciences 0302 clinical medicine immune system diseases Seizures medicine Humans In patient Optic neuritis Demyelinating Disorder Child Index case biology business.industry Brain medicine.disease Magnetic Resonance Imaging nervous system diseases 030104 developmental biology medicine.anatomical_structure Neurology Child Preschool Acute disseminated encephalomyelitis Immunology biology.protein Female Myelin-Oligodendrocyte Glycoprotein Neurology (clinical) Antibody business 030217 neurology & neurosurgery |
| Zdroj: | Journal of the neurological sciences. 387 |
| ISSN: | 1878-5883 |
| Popis: | We describe four patients who experienced optic neuritis (ON) and seizures and were found to have antibodies to myelin oligodendrocyte glycoprotein (MOG) in serum. The index case was a previously healthy 39-year-old man who developed steroid dependent ON and had a generalized seizure when steroids were tapered. He tested positive for antibodies to MOG. We have reviewed the charts of all 11 anti-MOG antibody positive patients in our practice and found that 4 patients, all of whom had experienced one or more episodes of ON, also had a generalized seizure during the course of their illness. In 2 patients - including the index case - seizure occurred during steroid taper and in 2 others at the time of an episode of acute disseminated encephalomyelitis (ADEM). Association of anti-MOG antibodies and relapsing demyelinating disorders of the central nervous system is increasingly recognized. Testing for anti-MOG antibodies should be considered in patients with optic neuritis and seizures, especially in those with who also have a history of ADEM. |
| Databáze: | OpenAIRE |
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