Role of Lateral Hypothalamus in Acupuncture Inhibition of Cocaine Psychomotor Activity
Autor: | Scott C. Steffensen, Yeonhee Ryu, Suchan Chang, Sang Chan Kim, Hyung Kyu Kim, Bong Hyo Lee, Hee Young Kim, Kyle B. Bills, Yu Fan, Danbi Ahn, Han Byeol Jang |
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Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
medicine.medical_specialty Lateral hypothalamus QH301-705.5 Substance-Related Disorders media_common.quotation_subject Dopamine Stimulation Article Catalysis spinohypothalamic neurons Inorganic Chemistry 03 medical and health sciences 0302 clinical medicine Cocaine Internal medicine Acupuncture Extracellular Medicine Animals Humans Neurons Afferent Biology (General) Physical and Theoretical Chemistry QD1-999 Molecular Biology Spectroscopy media_common Psychomotor learning Acupuncture stimulation business.industry Addiction Organic Chemistry lateral hypothalamus General Medicine Computer Science Applications Peripheral Rats Chemistry 030104 developmental biology Endocrinology Needles Hypothalamic Area Lateral business 030217 neurology & neurosurgery Locomotion |
Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 5994, p 5994 (2021) International Journal of Molecular Sciences Volume 22 Issue 11 |
ISSN: | 1422-0067 |
Popis: | Acupuncture modulates the mesolimbic dopamine (DA) system an area implicated in drug abuse. However, the mechanism by which peripheral sensory afferents, during acupuncture stimulation, modulate this system needs further investigation. The lateral hypothalamus (LH) has been implicated in reward processing and addictive behaviors. To investigate the role of the LH in mediating acupuncture effects, we evaluated the role of LH and spinohypothalamic neurons on cocaine-induced psychomotor activity and NAc DA release. Systemic injection of cocaine increased locomotor activity and 50 kHz ultrasonic vocalizations (USVs), which were attenuated by mechanical stimulation of needles inserted into HT7 but neither ST36 nor LI5. The acupuncture effects were blocked by chemical lesions of the LH or mimicked by activation of LH neurons. Single-unit extracellular recordings showed excitation of LH and spinohypothalamic neurons following acupuncture. Our results suggest that acupuncture recruits the LH to suppress the mesolimbic DA system and psychomotor responses following cocaine injection. |
Databáze: | OpenAIRE |
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