The effects of the administration routes on the biliary excretion of antibiotics
| Autor: | Masaru Yamazaki, Sawako Takase, Harumasa Toya, Akira Kamada |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Antibiotics Cefazolin Pharmacology Injections Intramuscular Route of administration Pharmacokinetics Internal medicine Medicine Animals Bile business.industry Aminoglycoside Anti-Bacterial Agents Kinetics Endocrinology Biliary tract Injections Intravenous Gentamicin Rabbits Gentamicins business Intramuscular injection medicine.drug |
| Zdroj: | Journal of pharmacobio-dynamics. 7(3) |
| ISSN: | 0386-846X |
| Popis: | The effects of the administration routes on the biliary excretion of gentamicin and cefazolin were investigated in male white rabbits. The administration routes studied were intravenous, intramuscular injection and injection into portal vein. In both antibiotics, total excretion into bile was the highest when drug was administered by the injection into portal vein. In case of gentamicin, the bile level above MIC (against P.aeruginosa) could be obtained only by the administration into portal vein. These results indicate that the administration into portal vein is useful clinically, for the drug delivery to biliary tract, especially in drugs like aminoglycoside antibiotics which have an extremely low rate of transfer to the bile. |
| Databáze: | OpenAIRE |
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