Subcellular localization of anthracyclines in cultured rat cardiomyoblasts as possible predictors of cardiotoxicity
| Autor: | Krzysztof Kik, Kazimierz Studzian, Malgorzata Strek, Leszek Szmigiero, Irena Oszczapowicz, Malgorzata Lukawska |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Anthracycline
Daunorubicin Formamidinoanthracyclines Biology Pharmacology Structure-Activity Relationship In vivo Cellular uptake medicine Animals Pharmacology (medical) Doxorubicin Anthracyclines Cytotoxicity Cell Nucleus Cardiotoxicity Preclinical Studies Subcellular localization Cell Cycle Cell cycle Molecular biology Rats Rat cardiomyoblasts DNA-Binding Proteins Oncology Myoblasts Cardiac medicine.drug |
| Zdroj: | Investigational New Drugs |
| ISSN: | 1573-0646 0167-6997 |
| Popis: | SummaryIn this study, we compared the cellular uptake, intracellular localization and cytotoxicity of two groups of anthracycline derivatives in cultured H9c2(2-1) rat cardiomyoblasts. The first group consisted of doxorubicin (DOX) and two of its derivatives containing a formamidino group (–N = CH–NP = 0.029). A correlation was found between the accumulation of the tested anthracyclines in the nuclei of cardiomyoblasts and their cardiotoxicity in vivo, which was observed in our previous study. We suggest that cytotoxicity and the anthracycline accumulation level in the nuclei of cultured cardiomyoblasts could be used for early prediction of their cardiotoxicity. |
| Databáze: | OpenAIRE |
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