Prevalence and prognostic relevance of myocardial inflammation and cardiotropic viruses in non-ischemic dilated cardiomyopathy
| Autor: | Virginija Grabauskienė, Dainius Daunoravicius, Kestutis Rucinskas, Vytė Valerija Maneikienė, Vaida Baltrūnienė, Edvardas Žurauskas, Artūras Jakubauskas, Jelena Čelutkienė, Ieva Kažukauskienė |
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| Rok vydání: | 2019 |
| Předmět: |
Cardiomyopathy
Dilated medicine.medical_specialty Myocarditis medicine.medical_treatment Biopsy Inflammation Disease 030204 cardiovascular system & hematology Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Prevalence Humans cardiovascular diseases chronic heart failure dilated cardiomyopathy myocardial inflammation prognosis viruses Heart transplantation Proportional hazards model business.industry Myocardium Dilated cardiomyopathy General Medicine medicine.disease Prognosis Viruses Etiology Cardiology cardiovascular system Immunohistochemistry medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | Cardiology journal, Gdansk : Via Medica, 2020, first on line, p. [1-24] Cardiology journal, Gdansk : Via Medica, 2022, vol. 29, no. 3, p. 441-453 |
| ISSN: | 1898-018X 1897-5593 |
| Popis: | Non-ischemic dilated cardiomyopathy (DCM) is a heterogeneous disease with a spectrum of etiological factors. However, subsets of the disease are not well-characterized with respect to these factors. The aim of this study was to evaluate the prevalence of myocardial inflammation and cardiotropic viruses in DCM patients and their impact on clinical outcome.Fifty-seven patients with DCM underwent endomyocardial biopsy between 2010 and 2013. Biopsies were analyzed by polymerase chain reaction (PCR) for the presence of cardiotropic viruses, and inflammatory cell infiltration was assessed by immunohistochemistry. During a 5-year follow-up, 27 (47%) patients reached the composite outcome measure: heart transplantation, left ventricle assist device implantation or cardiovascular-related death.Thirty-one (54%) patients had myocardial inflammation and cardiotropic viruses were detected in 29 (52%). The most frequent viruses were parvovirus B19 and human herpesvirus type-6. Four specific sub-groups were distinguished by PCR and immunohistochemistry: virus-positive (chronic) myocarditis, autoreactive inflammatory DCM, viral DCM, non-inflammatory DCM. The presence of a viral genome in myocardium or diagnosis of inflammatory DCM did not predict the outcome of composite outcome measures (p0.05). However, univariate Cox regression and survival function estimation revealed an association between inflammation by a high number of T-cells and poor prognosis.This study has shown that two markers - cardiotropic viruses and myocardial inflammation - are prevalent among DCM patients. They are also helpful in identifying sub-groups of DCM. An increased number of T-lymphocytes in the myocardium is a predictor of poor mid-term and long-term prognosis. |
| Databáze: | OpenAIRE |
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