Nicotine gum in smoking cessation: A placebo-controlled, double-blind trial
| Autor: | Murray E. Jarvik, Laura L. Read, Alan B. Forsythe, Mark L. Elliott, Avraham Schweiger, Nina G. Schneider |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Adult
Male Nicotine medicine.medical_specialty Nicotine Chewing Gum media_common.quotation_subject medicine.medical_treatment Administration Oral Medicine (miscellaneous) Smoking Prevention Toxicology Placebo law.invention Double-Blind Method Randomized controlled trial law Internal medicine medicine Humans media_common business.industry Abstinence Surgery Clinical trial Psychiatry and Mental health Clinical Psychology Nicotine gum Smoking cessation Female business Follow-Up Studies medicine.drug |
| Zdroj: | Addictive Behaviors. 8:253-261 |
| ISSN: | 0306-4603 |
| Popis: | Sixty subjects were run in a study comparing the use of nicotine gum with placebo gum during cessation from smoking. Subjects were given clinic support and chewed the gum ad libitum. A survival analysis showed the two groups differed significantly in successful abstinence over time (p less than .03). Differences between groups appeared early (within weeks) and, at six months, a 28% superiority of nicotine over placebo gum was demonstrated with mean success rates of 48% and 20%, respectively. Between six months and one year, relapse in the nicotine group accounted for the 30% vs. 20% success rates for nicotine and placebo observed at one year. In a pilot study ("dispensary") testing the efficacy of the two gums when intervention was minimal, subjects in both groups resumed smoking within the first two weeks. The enhanced short-term success rates with nicotine gum in the clinic study are attributed to an effective interaction between use of the active preparation and clinic support. Long-term cessation may require extended maintenance procedures and/or an identification of optimal gum use. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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