Reduction of hospitalizations with diarrhea among children aged 0–5 years in Nouakchott, Mauritania, following the introduction of rotavirus vaccine
| Autor: | Mohammed Benhafid, Jorg Heukelbach, Mohamed Val El-Mami, Abdelkarim Filali-Maltouf, Jacqueline E. Tate, Mariem Sidatt, Abdellahi Weddih, Umesh D. Parashar, Sid'Ahmed Dahdi, Khattry Makhalla, Aly Cheybany Cheikh Ahmed, Mohamed-Lemine Cheikh-brahim Ahmed |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Diarrhea
Male Pediatrics medicine.medical_specialty Referral Age and sex medicine.disease_cause Rotavirus vaccination Rotavirus Infections Feces 03 medical and health sciences 0302 clinical medicine 030225 pediatrics Rotavirus medicine Humans Registries 030212 general & internal medicine Retrospective Studies General Veterinary General Immunology and Microbiology Immunization Programs business.industry Public health Infant Newborn Mauritania Rotavirus Vaccines Public Health Environmental and Occupational Health Infant Rotavirus vaccine Gastroenteritis Hospitalization Infectious Diseases Child Preschool Hospital admission Molecular Medicine Female medicine.symptom business Sentinel Surveillance |
| Zdroj: | Vaccine. 37:1407-1411 |
| ISSN: | 0264-410X |
| DOI: | 10.1016/j.vaccine.2019.01.078 |
| Popis: | Introduction: Rotavirus vaccine was introduced in Mauritania in December 2014. We investigated hospitalizations with diarrhea during pre and post-vaccination periods among children aged 0-5 years in Nouakchott, the capital of Mauritania. Methods: We conducted a retrospective review of hospital admission registries from November 1st 2012 through October 31th 2017 at all referral hospitals in Nouakchott. We described admissions of children aged 0-5 years by diagnosis, data of admission, age and sex, and compared the proportion of all childhood hospitalizations with diarrhea before and after rotavirus vaccine introduction. Results: In total, 6552 (19%) of all 34,329 hospitalizations in 0-5 year-olds had diarrhea. Of these, 3523/16,952 (20.7%) were recorded during the pre-vaccine period, 1373/6897 (19.9%) during the transition period (November 2014-October 2015), and 1656/10,480 (15.8%) during the post-vaccination period. The proportion of all childhood hospitalizations with diarrhea during the pre-vaccine period was 22.6% among males and 18.7% among females. Approximately one third (32.3%) of hospitalizations with diarrhea occurred in children aged 6-11 months. During the post-vaccination period, the proportion of hospitalizations with diarrhea declined by 24%, and the highest reduction (74%) was observed in children aged 2 to 5 years (P < 0.001). Conclusions: The proportion of childhood hospitalizations with diarrhea in Nouakchott was reduced by about one fourth after introduction of rotavirus vaccination in Mauritania, indicating a major impact for public health for children in the capital city. (C) 2019 Elsevier Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
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