Embryonic and Adult-Derived Resident Cardiac Macrophages Are Maintained through Distinct Mechanisms at Steady State and during Inflammation
| Autor: | Stoyan Ivanov, Ansuman T. Satpathy, Dorothy K. Sojka, Slava Epelman, Wayne M. Yokoyama, Emil R. Unanue, Babak Razani, Ismail Sergin, Joel D. Schilling, Reto A. Schwendener, Gwendalyn J. Randolph, Thaddeus Brija, Kory J. Lavine, E. Camilla Forsberg, Anna E. Beaudin, Boris Calderon, Emmanuel L. Gautier, Marco Colonna, Javier A. Carrero, Douglas L. Mann |
|---|---|
| Přispěvatelé: | University of Zurich, Mann, Douglas L |
| Jazyk: | angličtina |
| Předmět: |
CCR2
Receptors CCR2 Phagocytosis Immunology Antigen presentation Inflammation Mice Transgenic Biology Article Monocytes Fetal Development Mice medicine Immunology and Allergy Myocyte Macrophage Antigens Ly Homeostasis Animals Cell Lineage Myocytes Cardiac Efferocytosis Cells Cultured Yolk Sac 2403 Immunology Antigen Presentation Cell Death Monocyte Macrophages Myocardium 10061 Institute of Molecular Cancer Research Cell Differentiation Heart 2725 Infectious Diseases Mice Inbred C57BL Myocarditis Infectious Diseases medicine.anatomical_structure 2723 Immunology and Allergy cardiovascular system 570 Life sciences biology medicine.symptom Transcriptome |
| Zdroj: | Immunity. (1):91-104 |
| ISSN: | 1074-7613 |
| DOI: | 10.1016/j.immuni.2013.11.019 |
| Popis: | SummaryCardiac macrophages are crucial for tissue repair after cardiac injury but are not well characterized. Here we identify four populations of cardiac macrophages. At steady state, resident macrophages were primarily maintained through local proliferation. However, after macrophage depletion or during cardiac inflammation, Ly6chi monocytes contributed to all four macrophage populations, whereas resident macrophages also expanded numerically through proliferation. Genetic fate mapping revealed that yolk-sac and fetal monocyte progenitors gave rise to the majority of cardiac macrophages, and the heart was among a minority of organs in which substantial numbers of yolk-sac macrophages persisted in adulthood. CCR2 expression and dependence distinguished cardiac macrophages of adult monocyte versus embryonic origin. Transcriptional and functional data revealed that monocyte-derived macrophages coordinate cardiac inflammation, while playing redundant but lesser roles in antigen sampling and efferocytosis. These data highlight the presence of multiple cardiac macrophage subsets, with different functions, origins, and strategies to regulate compartment size. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|