Frameless stereotaxic radiosurgery for multiple brain metastases
| Autor: | О. V. Zemskova, Е. G. Аndreychenko, А. B. Griazov, I. V. Кruchоk, I. N. Diкаn, I. P. Spasichenko, М. М. Denisenko |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Multivariate analysis
business.industry medicine.medical_treatment lcsh:R Clinical performance lcsh:Medicine multiple brain metastases frameless stereotaxic radiosurgery LINAC General Medicine Radiosurgery Radiation therapy Tumor Status Medicine Stereotaxic radiosurgery Karnofsky score business Nuclear medicine Median survival |
| Zdroj: | Medicni perspektivi (Medical perspectives); Том 19, № 2 (2014); 45-52 Медичні перспективи; Том 19, № 2 (2014); 45-52 Medičnì Perspektivi, Vol 19, Iss 2, Pp 45-52 (2014) |
| ISSN: | 2307-0404 |
| Popis: | Objective of this study was to retrospectively evaluate the effectiveness of frameless stereotaxic radiosurgery on LINAC for multiple (5–10) brain metastases and to identify prognostic factors related to survival and toxity. Materials and methods. 17 patients with multiple brain metastases, underwent frameless radiosurgery on Linac. The median tumors volume for radiosurgicaly treated lesions was 57 cm3 (range 20–94 cm3). The median prescribed radiation dose was 18 Gy (range 12–22 Gy). Univariate and multivariate analyses were used to determine significant prognostic factors affecting survival. Results. Overall median survival was 10 months after radiosurgery, and 1-year survival was 29,4%. Survival following radiosurgery was independent of patient’s age and sex, pretreatment of the cerebrum by using radiotherapy or surgery, number of brain metastases and their synchronization with the primary cancer, in contrast, survival was dependent on the patient's clinical performance score and extracranial tumor status. In multivariate regression analyses, the most important predictors associated with increased survival were KPS > or = 90 (P |
| Databáze: | OpenAIRE |
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