The Characteristics of 206 Long-Term Survivors with Peritoneal Metastases from Colorectal Cancer Treated with Curative Intent Surgery: A Multi-Center Cohort from PSOGI

Autor:	Paul H. Sugarbaker, Beate Rau, Hiroshi Nagata, Takanori Goi, Federico Coccolini, Yasuyuki Kamada, Miklos Acs, Mitsuhiro Morikawa, Olivier Glehen, Aditi Bhatt, Koji Murono, Emel Canbay, Mao Chih Hsieh, Yutaka Yonemura, Pompiliu Piso, Koya Hida, Shadin Ghabra, Kanji Katayama, Pierre Emmanuel Bonnot, Soichiro Ishihara
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Cancer Research medicine.medical_specialty Colorectal cancer colorectal cancer Article 03 medical and health sciences 0302 clinical medicine Interquartile range Medicine cytoreductive surgery RC254-282 Curative intent HIPEC business.industry Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cytoreductive surgery Long-term survivors Peritoneal metastasis medicine.disease Surgery Oncology 030220 oncology & carcinogenesis peritoneal metastasis long-term survivors Cohort Conventional PCI Peritoneal Cancer Index 030211 gastroenterology & hepatology Hyperthermic intraperitoneal chemotherapy business
Zdroj:	Cancers Volume 13 Issue 12 Cancers, Vol 13, Iss 2964, p 2964 (2021)
ISSN:	2072-6694
Popis:	Simple Summary Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy improves survival in selected patients with peritoneal metastases from colorectal cancer (CRC). However, the characteristics of long-term survivors are not well documented. This study set out to investigate the patient characteristics associated with the long-term survival of peritoneal metastases from CRC. We retrospectively analyzed 206 long-term survivors who underwent CRS for peritoneal metastases from CRC. We found that most long-term survivors showed low peritoneal cancer index (PCI), low PCI of small bowel subsets, and complete cytoreduction (CC-0), while some exhibited characteristics considered associated with poor prognosis. Abstract Background: We conducted this study to review the patient characteristics associated with long-term survival in patients with peritoneal metastases from colorectal cancer who underwent cytoreductive surgery (CRS). Methods: We retrospectively investigated patients with peritoneal metastases from CRC treated with curative intent surgery with or without hyperthermic intraperitoneal chemotherapy at 13 institutions worldwide between January 1985 and April 2015 and survived longer than five years after the first CRS for peritoneal metastases. Clinical and oncological features and therapeutic parameters were described and analyzed. Results: Two hundred six long-term survivors were available for study. The median peritoneal cancer index (PCI) of this cohort was 4 (interquartile range (IQR), 2–7), and the median score of the small bowel regions of the PCI (SB-PCI) was 0 (IQR, 0–2). Complete cytoreduction (CC-0) was achieved in 180 (87.4%) patients. Recurrence was observed in 122 (59.2%) patients at a median of 1.8 (IQR, 1.2–2.6) years. Conclusions: While most long-term survivors showed low PCI/SB-PCI and CCR-0, some had characteristics considered associated with poor prognosis. Curative intent treatments may be considered in well-informed and fit patients showing negative factors affecting survival outcome.
Databáze:	OpenAIRE
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