Inhibition of Glucan Synthesis by Casein Polymers Crosslinked by Glutaraldehyde
| Autor: | Osamu Hayashida, Keiji Hasumi, Akira Endo, Fumiki Mori |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
chemistry.chemical_classification
biology Organic Chemistry Biological activity macromolecular substances General Medicine Dental plaque medicine.disease biology.organism_classification Applied Microbiology and Biotechnology Biochemistry Streptococcus sobrinus Analytical Chemistry stomatognathic diseases chemistry.chemical_compound Enzyme chemistry Biosynthesis Casein medicine Glutaraldehyde Molecular Biology Biotechnology Glucan |
| Zdroj: | Bioscience, biotechnology, and biochemistry. 62(1) |
| ISSN: | 0916-8451 |
| Popis: | Glutaraldehyde-crosslinked α-casein polymers with molecular masses of 1-5×10(5) were found to inhibit adhesive insoluble glucan formation catalyzed by glucan synthases from Streptococcus sobrinus B13, a cariogenic oral bacterium. Of the three subcomponents of the glucan synthases tested, primer-dependent insoluble glucan synthase was inhibited specifically by the M r~2.7×10(5) polymer at a concentration of 1.4-8.5 μg/ml. The polymer was also active in inhibiting the artificial plaque formation by S. sobrinus B13. |
| Databáze: | OpenAIRE |
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