Hepatotoxicity in the treatment of acute lymphoblastic leukaemia
Autor: | M. V. Squier, J. M. Topley, J. M. Chessells, J. Benson |
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Rok vydání: | 1979 |
Předmět: |
Cancer Research
medicine.medical_specialty Pathology Adolescent Biopsy medicine.medical_treatment Antineoplastic Agents Gastroenterology Liver Function Tests Internal medicine medicine Humans Child Chemotherapy medicine.diagnostic_test Mercaptopurine business.industry Liver Diseases Histology Leukemia Lymphoid Methotrexate Oncology Liver biopsy Portal fibrosis Pediatrics Perinatology and Child Health Every Three Weeks Chemical and Drug Induced Liver Injury business Liver function tests medicine.drug |
Zdroj: | Medical and Pediatric Oncology. 7:393-399 |
ISSN: | 1096-911X 0098-1532 |
DOI: | 10.1002/mpo.2950070415 |
Popis: | Serial liver function tests and percutaneous liver biopsies were performed on 21 children receiving treatment for acute lymphoblastic leukaemia (ALL). The patients received continuing chemotherapy either with daily 6-mercaptopurine and weekly methotrexate or with five-day pulses of these drugs every three weeks. Liver function tests were transiently abnormal in the majority of children, but the abnormalities bore no relationship to the histology of the liver biopsy. Mild inflammatory and fatty changes were commonly seen, and early portal fibrosis was found in three out of 16 patients biopsied at between 108–130 weeks on treatment. There was no correlation between treatment regime and results of biopsy. Three patients showed possible progression of abnormalities on repeat biopsy. The risk of development of portal fibrosis appears low after 2–3 years of continuing chemotherapy, but examination of liver histology may be indicated if more prolonged therapy is contemplated. |
Databáze: | OpenAIRE |
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