An immunohistologic study of the epithelial and lymphoid components of six thymomas
| Autor: | E. Cristen, R.O. van der Heul, W. Van Ewijk, T.H. van der Kwast, E. P. M. van Vliet |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Adult
Antigens Differentiation T-Lymphocyte Male Pathology medicine.medical_specialty Thymoma medicine.drug_class Population Monoclonal antibody Epithelium Pathology and Forensic Medicine Cytokeratin Antigen DNA Nucleotidylexotransferase HLA Antigens hemic and lymphatic diseases Myasthenia Gravis medicine Humans education Aged education.field_of_study biology Histocompatibility Antigens Class II Anemia Aplastic Antibodies Monoclonal Infant HLA-DR Antigens Thymus Neoplasms Middle Aged medicine.disease Phenotype medicine.anatomical_structure Child Preschool Antigens Surface biology.protein Keratins Female Antibody |
| Zdroj: | Human Pathology. 16:1001-1008 |
| ISSN: | 0046-8177 |
| Popis: | Six thymomas were classified histologically and studied immunohistochemically with a panel of mouse and rat monoclonal antibodies directed against thymic epithelial and lymphoid components. The antibodies included monoclonal antibodies directed against cytokeratin, medullary epithelial cells (ER-TR5), and HLA-DR and HLA-ABC antigens, as well as antibodies with specificity for thymocytes. Histologically, one thymoma was characterized by epithelial predominance (EP type), two showed lymphoid predominance (LP type), and two showed mixed lymphoid/epithelial composition (MLE type); one thymoma was a malignant pure epithelial thymoma (PE type). In the thymomas of the MLE and EP types the major populations of cells consisted of HLA-DR-negative, cytokeratin-positive epithelial cells with large ER-TR5-positive subpopulations (i.e., the phenotype of medullary epithelium). In the thymomas of the LP type, the neoplastic population was composed of cytokeratin-positive, ER-TR5-negative cells that expressed the HLA-DR antigen (i.e., the phenotype of cortical epithelium). The thymoma of the PE type consisted of cytokeratin-positive cells, some of which were ER-TR5- and HLA-DR-positive. Double immunofluorescence studies revealed the presence of varying numbers of additional nonepithelial (nonlymphoid) HLA-DR-positive cells in thymomas of the LP, MLE, and EP types. The intervening lymphoid population in the thymomas of the LP, MLE, and EP types consisted largely of cortical thymocytes, as defined by immunologic characterization. These results suggest that thymomas can be classified as medullary or cortical epithelial neoplasms on the basis of their immunologic phenotypes. |
| Databáze: | OpenAIRE |
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