Long-term postoperative control of eosinophilic chronic rhinosinusitis recurrence by inserting a steroid-eluting, sinus-bioabsorbable device reduces the dosage of oral steroid
| Autor: | Kazuki Goto, Shinichi Haruna, Takashi Kashiwagi, Wataru Konno, Yasuhiro Tsunemi |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Chronic rhinosinusitis Threshold test medicine.medical_treatment Triamcinolone Acetonide Steroid 03 medical and health sciences 0302 clinical medicine Recurrence Absorbable Implants Eosinophilia Eosinophilic medicine Humans Cellulose Oxidized Sinusitis 030223 otorhinolaryngology Glucocorticoids Sinus (anatomy) Rhinitis business.industry Endoscopy General Medicine Middle Aged Otorhinolaryngologic Surgical Procedures Surgery Nasal discharge medicine.anatomical_structure Otorhinolaryngology 030220 oncology & carcinogenesis Oral steroid Female business Nasal symptoms |
| Zdroj: | Auris Nasus Larynx. 46:365-373 |
| ISSN: | 0385-8146 |
| DOI: | 10.1016/j.anl.2018.09.001 |
| Popis: | Objective We employed a steroid-eluting, sinus-bioabsorbable device for local treatment after surgery for eosinophilic chronic rhinosinusitis (ECRS). One year later, we investigated its efficacy in suppressing recurrence and reducing the use of oral steroids. Methods At one year after ECRS surgery, both 18 cases treated with a postoperative steroid-eluting, sinus-bioabsorbable device (Post-ST group) and 25 cases receiving conventional postoperative therapy (Post-Con group) showed significant improvement in the nasal symptoms (nasal obstruction, nasal discharge and olfactory dysfunction), CT score and threshold test (discrimination test). Results The olfactory dysfunction, CT score and threshold test were significantly improved in the Post-ST group compared with the Post-Con group, but the polyp score was not. The mean total number of oral steroid tablets ingested during one year after surgery was 24.3 ± 2.8 tablets in the Post-ST group, which was significant lower than the 36.3 ± 3.7 tablets used in the Post-Con group. Conclusion The above results indicate that insertion of a steroid-eluting, sinus-bioabsorbable device after ECRS surgery can reduce the oral steroid intake while maintaining long-term suppression of disease recurrence. |
| Databáze: | OpenAIRE |
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