Transcriptomic analysis and ednrb expression in cochlear intermediate cells reveal developmental differences between inner ear and skin melanocytes
| Autor: | Claudia Cabrera, Tiantian Cai, Justine M. Renauld, William Paul Davis, Martin L. Basch |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.hormone stria vascularis cochlea Dermatology Biology Melanocyte Vestibular System General Biochemistry Genetics and Molecular Biology Article Endothelins Transcriptome 03 medical and health sciences Mice 0302 clinical medicine Downregulation and upregulation medicine otorhinolaryngologic diseases Animals Inner ear development Cochlea EdnrB Skin Vestibular system Neural crest Gene Expression Regulation Developmental intermediate cells Receptor Endothelin B Cell biology Mice Inbred C57BL melanocytes 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Ear Inner sense organs |
| Zdroj: | Pigment cell & melanoma research |
| ISSN: | 1755-148X 1755-1471 |
| Popis: | In the inner ear, the neural crest gives rise to the glia of the VIII ganglion and two types of melanocytic cells: The pigmented cells of the vestibular system and intermediate cells of the stria vascularis. We analyzed the transcriptome of neonatal intermediate cells in an effort to better understand the development of the stria vascularis. We found that the expression of endothelin receptor B, which is essential for melanocyte development, persists in intermediate cells long after birth. In contrast, skin melanocytes rapidly downregulate the expression of EdnrB. Our findings suggest that endothelins might have co-opted new functions in the inner ear during evolution of the auditory organ. |
| Databáze: | OpenAIRE |
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