Development of functional lab-on-a-chip on polymer for point-of-care testing of metabolic parameters
| Autor: | Chien-Chong Hong, Jaephil Do, Junhai Kai, Se Hwan Lee, Joseph H. Nevin, Gregory Beaucage, Jungyup Han, Chuan Gao, Chong H. Ahn |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Blood Glucose
Spectrum analyzer Engineering business.industry Point-of-Care Systems Microfluidics Biomedical Engineering Bioengineering General Chemistry Lab-on-a-chip Biochemistry law.invention Cartridge Cable gland Sampling (signal processing) law Lab-On-A-Chip Devices Pinch valve Microchip Analytical Procedures Lactates Electronic engineering Fluidics Lactic Acid business Blood Chemical Analysis |
| Zdroj: | Lab on a Chip. 8:2113 |
| ISSN: | 1473-0189 1473-0197 |
| DOI: | 10.1039/b811169c |
| Popis: | This paper presents the development of an easy-to-handle and disposable clinical diagnostic lab-on-a-chip using fully integrated plastic microfluidic components, which has the sampling/identifying capability to make fast and reliable measurements of metabolic parameters from human whole blood. A smart and functional lab-on-a-chip cartridge, which incorporates a full on-chip auto-calibration function for in the field applications, has been developed, and then fully characterized using a portable analyzer (3 (1/4)''x 5''x 1'') with multi-analyte detection capability. In addition, several new approaches in realizing smart and functional lab-on-a-chips on polymer have been adopted, which include the pinch valve for automatic fluidic sealing, a by-pass channel as the sampling indicator, and a robust connector design for long analyzer lifetimes. Metabolic parameters such as glucose, lactate, and partial oxygen from human whole blood have been successfully measured using the functional polymer lab-on-a-chips and the portable analyzer developed in this work. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|