Aerobic exercise reduces biomarkers related to cardiovascular risk among cleaners: effects of a worksite intervention RCT

Autor: Andreas Holtermann, Mette Korshøj, Marie Højbjerg Ravn, Peter Krustrup, Åse Marie Hansen
Rok vydání: 2015
Předmět:
Male
Disease
030204 cardiovascular system & hematology
Fibrinogen
law.invention
chemistry.chemical_compound
0302 clinical medicine
Randomized controlled trial
Risk Factors
law
030212 general & internal medicine
Workplace
Health Education
Diurnal measurements
biology
Research Support
Non-U.S. Gov't
Housekeeping
Middle Aged
Cardiovascular disease
Household Work
C-Reactive Protein
Cardiovascular Diseases
Randomized Controlled Trial
Original Article
Female
RCT
medicine.drug
Adult
Aerobic workload
medicine.medical_specialty
Health Promotion
Blue-collar workers
03 medical and health sciences
Worksite intervention
Internal medicine
Journal Article
medicine
Humans
Aerobic exercise
Exercise
Occupational Health
Triglycerides
Objective measurements
Triglyceride
Cholesterol
business.industry
Cholesterol
HDL
C-reactive protein
Public Health
Environmental and Occupational Health
Cholesterol
LDL
chemistry
biology.protein
Physical therapy
business
Biomarkers
Lipoprotein
Zdroj: Korshøj, M, Ravn, M H, Holtermann, A, Hansen, Å M & Krustrup, P 2016, ' Aerobic exercise reduces biomarkers related to cardiovascular risk among cleaners : effects of a worksite intervention RCT ', International Archives of Occupational and Environmental Health, vol. 89, no. 2, pp. 239-249 . https://doi.org/10.1007/s00420-015-1067-5
International Archives of Occupational and Environmental Health
ISSN: 1432-1246
0340-0131
DOI: 10.1007/s00420-015-1067-5
Popis: PURPOSE: Blue-collar workers have an increased risk of cardiovascular disease. Accordingly, elevated levels of biomarkers related to risk of cardiovascular disease, such as high-sensitive C-reactive protein, have been observed among blue-collar workers. The objective was to examine whether an aerobic exercise worksite intervention changes the level of inflammation biomarkers among cleaners.METHODS: The design was a cluster-randomized controlled trial with 4-month worksite intervention. Before the 116 cleaners aged 18-65 years were randomized, they signed an informed consent form. The reference group (n = 59) received lectures, and the aerobic exercise group (n = 57) performed worksite aerobic exercise (30 min twice a week). Levels of biomarkers (high-sensitive C-reactive protein, fibrinogen, cholesterol, low- and high-density lipoprotein cholesterol and triglyceride) were collected at baseline and after 4 months. A repeated-measure, multi-adjusted, mixed-model intention-to-treat analysis was applied to compare between-group differences. The study was registered as ISRCTN86682076.RESULTS: Significant (p < 0.05) between-group reductions from baseline to follow-up were found for high-sensitive C-reactive protein (-0.54 ± 0.20 µg/ml; 95 % CI -0.94, -0.14), low-density lipoprotein cholesterol (-0.32 ± 0.11 mmol/L; 95 % CI -0.54, -0.10) and the ratios of LDL/HDL (-0.30 ± 0.08; 95 % CI -0.46, -0.14), and LDL/TC cholesterol (-0.04 ± 0.02; 95 % CI -0.07, -0.01).CONCLUSION: This study indicates that an aerobic exercise intervention among cleaners leads to reduced levels of high-sensitive C-reactive protein and low-density lipoprotein cholesterol, and an unaltered level of fibrinogen. The aerobic exercise seems to improve inflammatory levels and lipoprotein profile among cleaners, with no signs of cardiovascular overload.
Databáze: OpenAIRE
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