Comparison of Lung Clearance Index and Magnetic Resonance Imaging for Assessment of Lung Disease in Children with Cystic Fibrosis
| Autor: | Simon Y. Graeber, Hans-Ulrich Kauczor, Marcus A. Mall, Mark O. Wielpütz, Michael Puderbach, Monika Eichinger, Olaf Sommerburg, Cornelia Joachim, Mirjam Stahl |
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| Rok vydání: | 2016 |
| Předmět: |
Pulmonary and Respiratory Medicine
Male medicine.medical_specialty Adolescent Cystic Fibrosis Lung Clearance Index Mri studies Critical Care and Intensive Care Medicine Cystic fibrosis 030218 nuclear medicine & medical imaging 03 medical and health sciences Young Adult 0302 clinical medicine Antibiotic therapy Forced Expiratory Volume Germany medicine Humans Prospective Studies Child Lung Early onset medicine.diagnostic_test business.industry Pulmonary Gas Exchange Infant Magnetic resonance imaging medicine.disease Magnetic Resonance Imaging Respiratory Function Tests Clinical trial Cross-Sectional Studies 030228 respiratory system Breath Tests Lung disease Spirometry Child Preschool Disease Progression Female Radiology business |
| Zdroj: | American journal of respiratory and critical care medicine. 195(3) |
| ISSN: | 1535-4970 |
| Popis: | Early onset and progression of lung disease in children with cystic fibrosis (CF) indicates that sensitive noninvasive outcome measures are needed for diagnostic monitoring and early intervention clinical trials. The lung clearance index (LCI) and chest magnetic resonance imaging (MRI) were shown to detect early lung disease in CF; however, the relationship between the two measures remains unknown.To correlate the LCI with abnormalities detected by MRI and compare the sensitivity of the two techniques to detect responses to therapy for pulmonary exacerbations in children with CF.LCI determined by age-adapted multiple breath washout techniques and MRI studies were performed in 97 clinically stable children with CF across the pediatric age range (0.2-21.1 yr). Furthermore, LCI (n = 26) or MRI (n = 10) were performed at the time of pulmonary exacerbation and after antibiotic therapy. MRI was evaluated using a dedicated morphofunctional score.The LCI correlated with the global MRI score as well as MRI-defined airway wall abnormalities, mucus plugging, and abnormal lung perfusion in infants and toddlers (P 0.05 to P 0.001) and in older children (P 0.001) with CF. LCI and MRI were sensitive to detect response to antibiotic therapy for pulmonary exacerbations.Our results indicate that LCI and MRI may be useful complementary tools for noninvasive monitoring and as quantitative endpoints in early intervention trials in children with CF. In this context, MRI enables detection of disease heterogeneity, including regional mucus plugging associated with abnormal lung perfusion in early CF lung disease. Clinical trial registered with www.clinicaltrials.gov (NCT 02270476). |
| Databáze: | OpenAIRE |
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