Mechanism of Human Fetal Membrane Biomechanical Weakening, Rupture and Potential Targets for Therapeutic Intervention
| Autor: | Robert M. Moore, Brian M. Mercer, Deepak Kumar, John J. Moore, Joseph M. Mansour |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Fetal Membranes
Premature Rupture Extraembryonic Membranes Bioinformatics Models Biological In vitro model 03 medical and health sciences 0302 clinical medicine Pregnancy Fetal membrane Lack of efficacy Humans Medicine 030212 general & internal medicine Progesterone 030219 obstetrics & reproductive medicine Thioctic Acid Tumor Necrosis Factor-alpha business.industry Infant Newborn Thrombin Granulocyte-Macrophage Colony-Stimulating Factor Obstetrics and Gynecology Preterm Births Human fetal Premature Birth Female business |
| Zdroj: | Obstetrics and Gynecology Clinics of North America. 47:523-544 |
| ISSN: | 0889-8545 |
| DOI: | 10.1016/j.ogc.2020.08.010 |
| Popis: | Using a novel in vitro model system combining biochemical/histologic with bioengineering approaches has provided significant insights into the physiology of fetal membrane weakening and rupture along with potential mechanistic reasons for lack of efficacy of currently clinically used agents to prevent preterm premature rupture of the membranes (pPROM) and preterm births. Likewise, the model has also facilitated screening of agents with potential for preventing pPROM and preterm birth. |
| Databáze: | OpenAIRE |
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