Analysis of serum gastrin‐17 and Helicobacter pylori antibody in healthy Chinese population

Autor: Wenjun Liu, Youxiang Sun, Yulin Yuan
Rok vydání: 2020
Předmět:
Male
0301 basic medicine
Clinical Biochemistry
Gastroenterology
0302 clinical medicine
Disease Screening
gender
Immunology and Allergy
Medicine
Research Articles
Gastrin
Aged
80 and over
biology
Hematology
Middle Aged
Antibodies
Bacterial
Medical Laboratory Technology
030220 oncology & carcinogenesis
Helicobacter pylori antibody
Female
Antibody
Research Article
Adult
Microbiology (medical)
China
medicine.medical_specialty
Stomach Diseases
Helicobacter Infections
Young Adult
03 medical and health sciences
Internal medicine
Gastrins
gastrin
Humans
Typing
Aged
Retrospective Studies
Helicobacter pylori
business.industry
Biochemistry (medical)
Public Health
Environmental and Occupational Health
Cancer
gastric disease
biology.organism_classification
medicine.disease
Serum gastrin
030104 developmental biology
age
biology.protein
business
Helicobacter pylori Antibody
Zdroj: Journal of Clinical Laboratory Analysis
ISSN: 1098-2825
0887-8013
DOI: 10.1002/jcla.23518
Popis: Background Gastrin‐17 (G‐17) and Helicobacter pylori (H pylori) antibody are widely used in the screening of gastric diseases, especially in gastric cancer. In this study, we aimed to evaluate the value of G‐17 and H pylori antibody in gastric disease screening. Methods Healthy males and females (1368 and 1212, respectively) aged between 21‐80 years were recruited for the study. Serum G‐17 value was measured using ELISA, and H pylori antibodies were measured using Western blotting. Statistical analyses were performed using the chi‐square, Mann‐Whitney U, and Kruskal‐Wallis H tests. Results Serum G‐17 level was higher in the H pylori‐positive group than in the negative group. Serum G‐17 level was higher in the type 1 H pylori‐positive group than in the type 2 H pylori‐positive group. Further, serum G‐17 level was higher in females than in males and showed significant differences among different age‐groups, with changes in trend proportional to the age. The positive rate of H pylori infection in all the subjects was 58.29% and did not show a significant difference between males and females. However, it showed significant differences among different age‐groups, with the changing trend proportional to the age. Conclusion Analysis of serum G‐17 level and H pylori antibody typing is valuable in gastric disease screening. Every laboratory should establish its own reference interval for G‐17 level.
Serum G‐17 level was higher in females than in males, and the changing trend of serum G‐17 level was proportional to age.
Databáze: OpenAIRE
Externí odkaz: