Novel free-circulating and extracellular vesicle-derived miRNAs dysregulated in Duchenne muscular dystrophy
| Autor: | Volker Straub, Jennifer E. Morgan, Thomas Voit, Valeria Ricotti, Laurent Servais, Joana Domingos, Jan J.G.M. Verschuuren, L. Phillips, Imelda J. M. de Groot, Francesco Muntoni, Pierpaolo Ala, V. Selby, Andreea Mihaela Seferian, Erik H. Niks, D. Scaglioni, Yvonne D. Krom, F. Catapano, K. Maresh |
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| Rok vydání: | 2020 |
| Předmět: |
Duchenne muscular dystrophy
musculoskeletal diseases congenital hereditary and neonatal diseases and abnormalities Cancer Research Corticosteroid treatment Biology Age and sex corticosteroids Downregulation and upregulation Adrenal Cortex Hormones Mirna expression microRNA Genetics medicine Humans Mirna profiling Circulating MicroRNA Longitudinal Studies plasma Liquid Biopsy biomarkers Extracellular vesicle Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3] medicine.disease microRNAs nervous system diseases Muscular Dystrophy Duchenne Gene Expression Regulation Cancer research extracellular vesicles |
| Zdroj: | Epigenomics, 12, 1899-1915 Epigenomics, 12, 21, pp. 1899-1915 Epigenomics, 12(21), 1899-1915. FUTURE MEDICINE LTD |
| ISSN: | 1750-192X 1750-1911 |
| Popis: | Item does not contain fulltext Aim: To perform cross-sectional and longitudinal miRNA profiling in plasma from Duchenne muscular dystrophy (DMD) subjects and find non-invasive biomarkers in DMD. Subjects/materials & methods: Plasma was collected from 14 age and sex matched controls and 46 DMD subjects. Free-circulating and extracellular vesicle (EV)-derived miRNA expression was measured by RT-qPCR. Results: Free-circulating and EVs derived miR-29c-3p and miR-133a-3p are dysregulated in DMD subjects. Free-circulating and EV-derived miR-29c-3p are reduced in DMD subjects undergoing daily corticosteroid treatment. Free-circulating miR-1-3p and miR-122-5p are longitudinally upregulated in ambulant DMD subjects. Conclusion: We detected novel free-circulating and EV-derived dysregulated miRNAs in plasma from DMD subjects and characterized the longitudinal profile of free-circulating miRNA on plasma from DMD subjects. |
| Databáze: | OpenAIRE |
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